Stadium: Tullio Field Round: 1
| NCAAF | 2022/11/05 18:00 | Seton Hill Griffins v Mercyhurst | L | 7-0 |
| NCAAF | 2021/10/09 16:00 | Mercyhurst v Seton Hill Griffins | L | 17-19 |
| NCAAF | 2019/10/19 16:00 | Mercyhurst v Seton Hill Griffins | L | 20-30 |
| NCAAF | 2018/10/13 16:00 | Seton Hill Griffins v Mercyhurst | L | 34-33 |
| NCAAF | 2022/11/12 17:00 | Mercyhurst v Bloomsburg Huskies | L | 13-16 |
| NCAAF | 2022/11/05 18:00 | Seton Hill Griffins v Mercyhurst | L | 7-0 |
| NCAAF | 2022/10/29 16:00 | Mercyhurst v California Vulcans | L | 20-44 |
| NCAAF | 2022/10/22 16:00 | Gannon University Golden Knights v Mercyhurst | L | 49-14 |
| NCAAF | 2022/10/15 22:00 | Mercyhurst v Clarion Golden Eagles | L | 21-23 |
| NCAAF | 2022/10/08 22:00 | Slippery Rock v Mercyhurst | L | 31-17 |
| NCAAF | 2022/10/01 18:00 | Mercyhurst v Edinboro | L | 13-16 |
| NCAAF | 2022/09/24 20:00 | Iup Crimson Hawks v Mercyhurst | L | 33-16 |
| NCAAF | 2022/11/12 17:00 | Seton Hill Griffins v Millersville University of Pennsylvania Marauders | L | 10-14 |
| NCAAF | 2022/11/05 18:00 | Seton Hill Griffins v Mercyhurst | W | 7-0 |
| NCAAF | 2022/10/29 16:00 | Edinboro v Seton Hill Griffins | W | 14-45 |
| NCAAF | 2022/10/22 18:00 | Iup Crimson Hawks v Seton Hill Griffins | L | 44-7 |
| NCAAF | 2022/10/15 22:00 | Seton Hill Griffins v California Vulcans | L | 14-21 |
| NCAAF | 2022/10/08 20:00 | Seton Hill Griffins v Clarion Golden Eagles | L | 13-40 |
| NCAAF | 2022/10/01 16:00 | Gannon University Golden Knights v Seton Hill Griffins | L | 21-10 |
| NCAAF | 2022/09/24 22:00 | Slippery Rock v Seton Hill Griffins | L | 30-2 |