| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 09/27 17:00 | 1 | Maine Maritime Mariners v Keystone Giants | W | 22-47 |
| 09/20 17:00 | 1 | Keystone Giants v Southern Virginia Knights | L | 0-42 |
| 11/09 17:00 | 1 | Keystone Giants v Juniata Eagles | L | 38-43 |
| 11/02 16:00 | 1 | Catholic Cardinals v Keystone Giants | L | 42-24 |
| 10/26 17:00 | 1 | Lycoming Warriors v Keystone Giants | L | 31-28 |
| 10/19 16:00 | 1 | Keystone Giants v Wilkes Colonels | L | 24-69 |
| 10/12 17:00 | 1 | Susquehanna Crusaders v Keystone Giants | L | 79-6 |
| 10/05 17:00 | 1 | Keystone Giants v Moravian Greyhounds | L | 14-55 |
| 09/28 16:00 | 1 | Keystone Giants v Hobart Statesmen | L | 9-52 |
| 09/21 16:00 | 1 | St John Fisher Cardinals v Keystone Giants | L | 42-40 |
| 09/14 17:00 | 1 | Keystone Giants v Hartwick Hawks | W | 51-26 |
| 09/07 16:00 | 1 | Misericordia Cougars v Keystone Giants | L | 24-14 |
| 11/04 16:00 | 1 | Juniata Eagles v Keystone Giants | W | 35-42 |
| 10/28 16:00 | 1 | Keystone Giants v Catholic Cardinals | L | 14-26 |
| 10/21 17:00 | 1 | Keystone Giants v Lycoming Warriors | L | 7-34 |
| 10/14 16:00 | 1 | Wilkes Colonels v Keystone Giants | L | 42-7 |
| 10/07 17:00 | 1 | Keystone Giants v Susquehanna Crusaders | L | 0-69 |
| 09/30 17:00 | 1 | Moravian Greyhounds v Keystone Giants | L | 58-34 |
| 09/23 22:00 | 1 | Hobart Statesmen v Keystone Giants | L | 43-10 |
| 09/16 17:00 | 1 | Keystone Giants v St John Fisher Cardinals | L | 20-35 |
| 09/09 17:00 | 1 | Hartwick Hawks v Keystone Giants | L | 31-21 |
| 09/02 16:00 | 1 | Keystone Giants v Gallaudet Bison | W | 27-6 |
| 11/12 17:00 | 1 | Dean Bulldogs v Keystone Giants | W | 44-45 |
| 11/05 17:00 | 1 | Keystone Giants v Suny Maritime Privateers | W | 21-20 |
| 10/22 16:00 | 1 | Keystone Giants v Castleton Spartans | L | 20-35 |
| 10/15 16:00 | 1 |
Anna Maria Amcats
v
Keystone Giants
|
W | 39-41 |
| 10/08 17:00 | 1 |
Alfred State Pioneers
v
Keystone Giants
|
L | 42-33 |
| 10/01 16:00 | 1 | Keystone Giants v Gallaudet Bison | L | 44-52 |
| 09/24 17:30 | 1 | Keystone Giants v Hobart Statesmen | L | 6-65 |
| 09/17 17:00 | 1 | William Paterson Pioneers v Keystone Giants | L | 27-20 |
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