Head to Head
| Chile Liga de Primera | 2022/07/10 22:00 | Colo Colo v La Serena | L | 3-0 |
| Chile Liga de Primera | 2022/02/13 21:00 | La Serena v Colo Colo | D | 1-1 |
| Chile Liga de Primera | 2021/10/20 17:00 | La Serena v Colo Colo | L | 1-4 |
| Chile Cup | 2021/07/05 00:00 | Colo Colo v La Serena | L | 4-0 |
| Chile Cup | 2021/07/01 19:30 | La Serena v Colo Colo | L | 1-3 |
| Chile Liga de Primera | 2021/06/06 22:00 | Colo Colo v La Serena | L | 2-0 |
| Chile Liga de Primera | 2020/12/08 21:30 | Colo Colo v La Serena | W | 0-2 |
| Chile Liga de Primera | 2020/03/07 15:00 | La Serena v Colo Colo | L | 1-2 |
| Chile Cup | 2017/08/03 00:00 | Colo Colo v La Serena | L | 4-0 |
| Chile Cup | 2017/07/09 19:30 | La Serena v Colo Colo | W | 4-1 |
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