Stadium: Cheek Field and Farris Stadium Round: 1
| NCAAF | 2022/11/12 18:00 | Centre Colonels v Millsaps Majors | W | 57-3 |
| NCAAF | 2022/11/05 18:00 | Birmingham Southern Panthers v Centre Colonels | L | 42-21 |
| NCAAF | 2022/10/29 16:00 | Centre Colonels v Trinity Tigers | L | 21-41 |
| NCAAF | 2022/10/22 18:00 | Hendrix Warriors v Centre Colonels | W | 42-45 |
| NCAAF | 2022/10/15 17:00 | Centre Colonels v Berry Vikings | L | 30-31 |
| NCAAF | 2022/10/08 17:00 | Centre Colonels v Sewanee Tigers | W | 35-16 |
| NCAAF | 2022/10/01 18:00 | Rhodes Lynx v Centre Colonels | W | 7-21 |
| NCAAF | 2022/09/24 18:30 | Trine Thunder v Centre Colonels | L | 17-0 |
| NCAAF | 2022/11/12 19:00 | Sul Ross State Lobos v Southwestern Pirates | L | 44-41 |
| NCAAF | 2022/11/05 18:00 | Southwestern Pirates v Texas Lutheran Bulldogs | L | 17-21 |
| NCAAF | 2022/10/29 18:00 | Austin Kangaroos v Southwestern Pirates | W | 29-40 |
| NCAAF | 2022/10/22 18:00 | Southwestern Pirates v Hardin Simmons Cowboys | L | 0-68 |
| NCAAF | 2022/10/15 19:00 | Howard Payne Yellow Jackets v Southwestern Pirates | L | 48-17 |
| NCAAF | 2022/10/01 23:00 | East Texas Baptist Tigers v Southwestern Pirates | L | 31-10 |
| NCAAF | 2022/09/24 23:00 | Southwestern Pirates v Mcmurry Warhawks | W | 38-33 |
| NCAAF | 2022/09/17 23:00 | Mary Hardin Baylor v Southwestern Pirates | L | 68-14 |