Stadium: Case Gym Round: 1
Home Manager: Maureen Magarity Away Manager: Melissa D'Amico
| WNCAAB | 2022/03/02 23:00 | Boston U (W) v Holy Cross (W) | W | 48-59 |
| WNCAAB | 2022/02/16 23:00 | Holy Cross (W) v Boston U (W) | L | 56-74 |
| WNCAAB | 2021/02/21 19:00 | Holy Cross (W) v Boston U (W) | W | 60-52 |
| WNCAAB | 2021/02/20 18:00 | Holy Cross (W) v Boston U (W) | L | 58-70 |
| WNCAAB | 2021/02/17 23:00 | Holy Cross (W) v Boston U (W) | L | 53-71 |
| WNCAAB | 2021/01/05 19:00 | Boston U (W) v Holy Cross (W) | L | 72-56 |
| WNCAAB | 2021/01/04 19:00 | Boston U (W) v Holy Cross (W) | L | 76-54 |
| WNCAAB | 2020/02/08 18:05 | Holy Cross (W) v Boston U (W) | L | 51-62 |
| NIT Women | 2022/03/16 23:00 | Holy Cross (W) v Columbia (W) | L | 69-80 |
| WNCAAB | 2022/03/08 00:00 | Navy (W) v Holy Cross (W) | L | 50-49 |
| WNCAAB | 2022/03/02 23:00 | Boston U (W) v Holy Cross (W) | W | 48-59 |
| WNCAAB | 2022/02/26 18:00 | Holy Cross (W) v Army (W) | W | 73-59 |
| WNCAAB | 2022/02/24 00:00 | Holy Cross (W) v Colgate (W) | W | 62-55 |
| WNCAAB | 2022/02/19 17:00 | Navy (W) v Holy Cross (W) | W | 57-63 |
| WNCAAB | 2022/02/16 23:00 | Holy Cross (W) v Boston U (W) | L | 56-74 |
| WNCAAB | 2022/02/12 17:00 | Bucknell Women v Holy Cross (W) | L | 66-49 |
| WNCAAB | 2022/03/10 23:00 | Boston U (W) v American (W) | L | 48-70 |
| WNCAAB | 2022/03/07 23:00 | Army (W) v Boston U (W) | W | 74-80 |
| WNCAAB | 2022/03/02 23:00 | Boston U (W) v Holy Cross (W) | L | 48-59 |
| WNCAAB | 2022/02/26 19:00 | Bucknell Women v Boston U (W) | W | 51-69 |
| WNCAAB | 2022/02/23 23:00 | Boston U (W) v Lafayette (W) | L | 52-58 |
| WNCAAB | 2022/02/19 18:00 | Colgate (W) v Boston U (W) | L | 64-61 |
| WNCAAB | 2022/02/16 23:00 | Holy Cross (W) v Boston U (W) | W | 56-74 |
| WNCAAB | 2022/02/12 19:00 | Boston U (W) v American (W) | L | 57-70 |