[21] OTT Senators 3-4 BUF Sabres [20] 2022-11-22 01:00
Stadium: KeyBank Center
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | W | 1-4 |
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | L | 1-4 |
| NHL | 2022/02/18 00:00 | OTT Senators v BUF Sabres | W | 3-1 |
| NHL | 2022/01/26 00:00 | BUF Sabres v OTT Senators | W | 0-5 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | L | 3-1 |
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | W | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | W | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | W | 1-3 |
Home History
| NHL | 2022/11/19 18:00 | NJ Devils v OTT Senators | L | 5-1 |
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | W | 1-4 |
| NHL | 2022/11/14 22:30 | NY Islanders v OTT Senators | L | 4-2 |
| NHL | 2022/11/12 18:00 | OTT Senators v PHI Flyers | W | 4-1 |
| NHL | 2022/11/11 00:00 | OTT Senators v NJ Devils | L | 3-4 |
| NHL | 2022/11/09 00:00 | VAN Canucks v OTT Senators | L | 6-4 |
| NHL | 2022/11/05 23:00 | PHI Flyers v OTT Senators | L | 2-1 |
| NHL | 2022/11/03 23:00 | VGS Golden Knights v OTT Senators | L | 5-4 |
Away History
| NHL | 2022/11/20 00:00 | BUF Sabres v TOR Maple Leafs | L | 2-5 |
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | L | 1-4 |
| NHL | 2022/11/16 00:00 | VAN Canucks v BUF Sabres | L | 5-4 |
| NHL | 2022/11/13 00:00 | BOS Bruins v BUF Sabres | L | 3-1 |
| NHL | 2022/11/11 00:00 | VGS Golden Knights v BUF Sabres | L | 7-4 |
| NHL | 2022/11/09 00:00 | ARZ Coyotes v BUF Sabres | L | 4-1 |
| NHL | 2022/11/05 23:00 | BUF Sabres v TB Lightning | L | 3-5 |
| NHL | 2022/11/04 23:00 | BUF Sabres v CAR Hurricanes | L | 3-5 |
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