[12] BUF Sabres 4-2 SJ Sharks [14] 2022-09-25 01:30
Stadium: SAP Center at San Jose
Home Manager: David Quinn Away Manager: Don Granato
Head to Head
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | L | 3-5 |
| NHL | 2019/10/22 23:00 | SJ Sharks v BUF Sabres | W | 3-4 |
| NHL | 2019/10/20 02:30 | BUF Sabres v SJ Sharks | W | 4-3 |
| NHL | 2018/11/28 00:00 | SJ Sharks v BUF Sabres | W | 2-3 |
| NHL | 2018/10/19 02:30 | BUF Sabres v SJ Sharks | L | 1-5 |
| NHL | 2017/10/28 17:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2017/10/13 02:30 | BUF Sabres v SJ Sharks | L | 2-3 |
Home History
| NHL | 2022/04/29 23:00 | CHI Blackhawks v BUF Sabres | W | 2-3 |
| NHL | 2022/04/28 23:00 | BUF Sabres v BOS Bruins | L | 0-5 |
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | W | 3-5 |
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
Away History
| NHL | 2022/04/30 02:00 | SJ Sharks v SEA Kraken | L | 0-3 |
| NHL | 2022/04/29 01:00 | SJ Sharks v EDM Oilers | L | 4-5 |
| NHL | 2022/04/27 02:30 | ANA Ducks v SJ Sharks | L | 5-2 |
| NHL | 2022/04/25 02:00 | SJ Sharks v VGS Golden Knights | W | 5-4 |
| NHL | 2022/04/24 00:00 | CHI Blackhawks v SJ Sharks | W | 1-4 |
| NHL | 2022/04/22 02:30 | STL Blues v SJ Sharks | L | 3-1 |
| NHL | 2022/04/20 02:30 | CLB Blue Jackets v SJ Sharks | W | 2-3 |
| NHL | 2022/04/17 22:00 | SJ Sharks v MIN Wild | L | 4-5 |
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