Stadium: Hart Center Arena
Home Manager: Tiffany Coll Away Manager: Maureen Magarity
| WNCAAB | 2022/01/26 22:00 | American (W) v Holy Cross (W) | L | 44-55 |
| WNCAAB | 2022/01/12 23:00 | Holy Cross (W) v American (W) | W | 39-52 |
| WNCAAB | 2020/02/29 19:00 | Holy Cross (W) v American (W) | L | 73-58 |
| WNCAAB | 2020/01/18 18:00 | Holy Cross (W) v American (W) | L | 72-59 |
| WNCAAB | 2019/02/27 23:05 | American (W) v Holy Cross (W) | W | 71-44 |
| WNCAAB | 2019/01/31 00:00 | American (W) v Holy Cross (W) | W | 70-58 |
| WNCAAB | 2018/02/21 16:30 | Holy Cross (W) v American (W) | W | 57-72 |
| WNCAAB | 2018/01/25 00:05 | American (W) v Holy Cross (W) | W | 68-63 |
| WNCAAB | 2022/11/18 00:00 | George Washington Women v American (W) | L | 67-62 |
| WNCAAB | 2022/11/10 01:00 | American (W) v DePaul (W) | L | 45-96 |
| WNCAAB | 2022/03/19 19:30 | American (W) v Michigan (W) | L | 39-74 |
| WNCAAB | 2022/03/13 07:27 | American (W) v Bucknell Women | W | 65-54 |
| WNCAAB | 2022/03/10 23:00 | Boston U (W) v American (W) | W | 48-70 |
| WNCAAB | 2022/03/08 00:00 | Lafayette (W) v American (W) | W | 48-54 |
| WNCAAB | 2022/03/03 00:00 | Lafayette (W) v American (W) | W | 48-62 |
| WNCAAB | 2022/02/26 21:00 | American (W) v Loyola Maryland (W) | W | 49-48 |
| WNCAAB | 2022/11/17 00:00 | New Hampshire (W) v Holy Cross (W) | W | 49-56 |
| WNCAAB | 2022/11/12 01:00 | Holy Cross (W) v Marquette (W) | L | 55-75 |
| WNCAAB | 2022/11/08 00:00 | Holy Cross (W) v Merrimack (W) | W | 67-39 |
| NIT Women | 2022/03/16 23:00 | Holy Cross (W) v Columbia (W) | L | 69-80 |
| WNCAAB | 2022/03/08 00:00 | Navy (W) v Holy Cross (W) | L | 50-49 |
| WNCAAB | 2022/03/02 23:00 | Boston U (W) v Holy Cross (W) | W | 48-59 |
| WNCAAB | 2022/02/26 18:00 | Holy Cross (W) v Army (W) | W | 73-59 |
| WNCAAB | 2022/02/24 00:00 | Holy Cross (W) v Colgate (W) | W | 62-55 |