Stadium: Winthrop Coliseum
Home Manager: Dave Dickerson Away Manager: Mark Prosser
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | L | 59-89 |
| NCAAB | 2022/01/26 23:00 | Winthrop v USC Upstate | L | 95-91 |
| NCAAB | 2020/12/13 19:00 | Winthrop v USC Upstate | L | 107-77 |
| NCAAB | 2020/12/12 21:00 | Winthrop v USC Upstate | L | 95-77 |
| NCAAB | 2020/03/05 17:00 | USC Upstate v Winthrop | L | 70-106 |
| NCAAB | 2020/02/27 23:00 | Winthrop v USC Upstate | L | 90-82 |
| NCAAB | 2020/01/24 00:00 | USC Upstate v Winthrop | L | 53-79 |
| NCAAB | 2019/01/19 21:30 | Winthrop v USC Upstate | L | 82-72 |
| NCAAB | 2022/03/22 00:00 | USC Upstate v South Alabama | L | 79-83 |
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | W | 80-74 |
| NCAAB | 2022/03/05 17:00 | USC Upstate v Longwood | L | 70-79 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/26 21:00 | Gardner Webb v USC Upstate | W | 70-72 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | L | 59-89 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | W | 78-73 |
| NCAAB | 2022/02/16 23:00 | Presbyterian v USC Upstate | W | 55-60 |
| NCAAB | 2022/03/06 17:00 | Longwood v Winthrop | L | 79-58 |
| NCAAB | 2022/03/05 19:00 | Gardner Webb v Winthrop | W | 67-76 |
| NCAAB | 2022/03/04 23:00 | High Point v Winthrop | W | 51-68 |
| NCAAB | 2022/02/26 21:00 | Charleston Southern v Winthrop | W | 86-92 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | W | 59-89 |
| NCAAB | 2022/02/19 21:30 | Winthrop v UNC Asheville | W | 84-79 |
| NCAAB | 2022/02/17 00:00 | Winthrop v Gardner Webb | W | 81-70 |
| NCAAB | 2022/02/12 21:30 | Presbyterian v Winthrop | W | 61-65 |