Stadium: Jack Breslin Students Events Center
Home Manager: Tom Izzo Away Manager: Mike Martin
| NCAAB | 2022/03/06 00:00 | Brown v Yale | L | 65-74 |
| NCAAB | 2022/02/26 23:00 | Columbia v Brown | W | 74-81 |
| NCAAB | 2022/02/19 23:00 | Pennsylvania v Brown | L | 89-88 |
| NCAAB | 2022/02/19 00:00 | Princeton v Brown | L | 69-50 |
| NCAAB | 2022/02/12 19:00 | Brown v Cornell | W | 81-80 |
| NCAAB | 2022/02/05 23:00 | Dartmouth v Brown | W | 60-62 |
| NCAAB | 2022/02/05 00:00 | Harvard v Brown | L | 65-50 |
| NCAAB | 2022/01/30 16:00 | Cornell v Brown | L | 74-72 |
| NCAAB | 2022/03/20 21:15 | Michigan State v Duke | L | 76-85 |
| NCAAB | 2022/03/19 01:40 | Davidson v Michigan State | W | 73-74 |
| NCAAB | 2022/03/12 20:30 | Michigan State v Purdue | L | 70-75 |
| NCAAB | 2022/03/11 23:30 | Michigan State v Wisconsin | W | 69-63 |
| NCAAB | 2022/03/10 23:30 | Maryland v Michigan State | W | 72-76 |
| NCAAB | 2022/03/06 21:30 | Maryland v Michigan State | W | 67-77 |
| NCAAB | 2022/03/04 00:00 | Michigan State v Ohio State | L | 69-80 |
| NCAAB | 2022/03/02 01:30 | Michigan State v Michigan | L | 70-87 |