Stadium: Alumni Stadium (Kentucky State University) Round: 1
| NCAAF | 2021/11/13 18:00 | Erskine Flying Fleet v Kentucky Thorobreds | W | 17-41 |
| NCAAF | 2021/11/06 17:00 | Kentucky Thorobreds v Central State | W | 63-0 |
| NCAAF | 2021/10/30 18:00 | Tuskegee v Kentucky Thorobreds | W | 35-42 |
| NCAAF | 2021/10/23 17:00 | Kentucky Thorobreds v Miles Golden Bears | L | 21-28 |
| NCAAF | 2021/10/16 17:00 | Edward Waters Tigers v Kentucky Thorobreds | W | 36-76 |
| NCAAF | 2021/10/09 18:00 | Kentucky Thorobreds v Lane College Dragons | W | 49-14 |
| NCAAF | 2021/10/02 17:00 | Kentucky Thorobreds v Savannah State | L | 17-21 |
| NCAAF | 2021/09/25 19:00 | Kentucky Thorobreds v Benedict College | W | 34-28 |
| NCAAF | 2021/11/13 18:00 | West Georgia v Delta State | L | 44-7 |
| NCAAF | 2021/11/06 19:00 | Delta State v Mississippi College Choctaws | W | 24-21 |
| NCAAF | 2021/10/30 19:00 | Delta State v Shorter | W | 14-13 |
| NCAAF | 2021/10/23 21:00 | West Alabama Tigers v Delta State | W | 30-35 |
| NCAAF | 2021/10/16 19:00 | Delta State v North Greenville Crusaders | L | 34-42 |
| NCAAF | 2021/10/09 23:00 | Valdosta State v Delta State | L | 55-0 |
| NCAAF | 2021/10/02 23:00 | Delta State v West Florida | L | 33-39 |
| NCAAF | 2021/09/25 19:00 | Jackson State v Delta State | L | 24-17 |