Louisville 13-26 Kentucky 2022-08-20 12:00
Stadium: Kroger Field Round: 1
Home Manager: Mark Stoops Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2019/11/30 17:00 | Louisville v Kentucky | L | 13-45 |
| NCAAF | 2018/11/25 00:00 | Kentucky v Louisville | L | 56-10 |
| NCAAF | 2017/11/25 17:00 | Louisville v Kentucky | W | 44-17 |
| NCAAF | 2016/11/26 17:00 | Kentucky v Louisville | L | 41-38 |
| NCAAF | 2015/11/28 17:00 | Kentucky v Louisville | W | 24-38 |
| NCAAF | 2014/11/29 17:00 | Louisville v Kentucky | W | 44-40 |
| NCAAF | 2012/09/02 12:00 | Louisville v Kentucky | W | 32-14 |
Home History
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
Away History
| NCAAF Bowl Games | 2022/01/01 18:00 | Kentucky v Iowa | W | 20-17 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | W | 52-21 |
| NCAAF | 2021/11/20 17:00 | New Mexico State v Kentucky | W | 16-56 |
| NCAAF | 2021/11/14 00:00 | Kentucky v Vanderbilt | W | 34-17 |
| NCAAF | 2021/11/06 23:00 | Tennessee v Kentucky | L | 45-42 |
| NCAAF | 2021/10/30 23:00 | Kentucky v Mississippi State | L | 17-31 |
| NCAAF | 2021/10/16 19:30 | Kentucky v Georgia | L | 13-30 |
| NCAAF | 2021/10/09 23:30 | LSU v Kentucky | W | 21-42 |
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