[1] Clemson 34-28 Florida State [3] 2022-09-19 07:30
Stadium: Bobby Bowden Field at Doak Campbell Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Mike Norvell
Head to Head
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | W | 20-30 |
| NCAAF | 2019/10/12 19:30 | Clemson v Florida State | W | 45-14 |
| NCAAF | 2018/10/27 16:00 | Florida State v Clemson | W | 10-59 |
| NCAAF | 2018/10/27 16:00 | Clemson v Florida State | W | 59-10 |
| NCAAF | 2017/11/11 20:30 | Florida State v Clemson | W | 14-31 |
| NCAAF | 2016/10/30 00:00 | Clemson v Florida State | W | 37-34 |
| NCAAF | 2015/11/07 20:30 | Clemson v Florida State | W | 23-13 |
| NCAAF | 2014/09/21 00:00 | Florida State v Clemson | L | 23-17 |
Home History
| NCAAF | 2022/09/18 00:00 | Louisiana Tech v Clemson | W | 20-48 |
| NCAAF | 2022/09/10 19:30 | Furman v Clemson | W | 12-35 |
| NCAAF | 2022/09/06 00:00 | Clemson v Georgia Tech | W | 41-10 |
| NCAAF Bowl Games | 2021/12/29 22:45 | Iowa State v Clemson | W | 13-20 |
| NCAAF | 2021/11/28 00:30 | Clemson v South Carolina | W | 30-0 |
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | W | 27-48 |
| NCAAF | 2021/11/13 17:00 | Connecticut v Clemson | W | 7-44 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
Away History
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | W | 35-31 |
| NCAAF | 2022/09/04 23:30 | Florida State v LSU | W | 24-23 |
| NCAAF | 2022/08/27 22:30 | Duquesne v Florida State | W | 7-47 |
| NCAAF | 2021/11/27 17:00 | Florida State v Florida | L | 21-24 |
| NCAAF | 2021/11/20 17:00 | Florida State v Boston College | W | 26-23 |
| NCAAF | 2021/11/13 20:30 | Miami Florida v Florida State | W | 28-31 |
| NCAAF | 2021/11/06 20:00 | NC State v Florida State | L | 28-14 |
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | L | 20-30 |
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