Indiana 39-31 Michigan State 2022-08-28 19:00
Stadium: Spartan Stadium Round: 1
Home Manager: Tom Allen Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | L | 20-15 |
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | W | 24-0 |
| NCAAF | 2019/09/28 19:30 | Indiana v Michigan State | L | 31-40 |
| NCAAF | 2018/09/22 23:30 | Michigan State v Indiana | L | 35-21 |
| NCAAF | 2017/10/21 19:30 | Indiana v Michigan State | L | 9-17 |
| NCAAF | 2016/10/02 00:00 | Michigan State v Indiana | W | 21-24 |
| NCAAF | 2015/10/24 19:30 | Michigan State v Indiana | L | 52-26 |
| NCAAF | 2014/10/18 19:30 | Indiana v Michigan State | L | 17-56 |
Home History
| NCAAF | 2021/11/27 20:30 | Indiana v Purdue | L | 7-44 |
| NCAAF | 2021/11/20 20:30 | Minnesota v Indiana | L | 35-14 |
| NCAAF | 2021/11/13 17:00 | Rutgers v Indiana | L | 38-3 |
| NCAAF | 2021/11/06 23:30 | Indiana v Michigan | L | 7-29 |
| NCAAF | 2021/10/30 16:00 | Indiana v Maryland | L | 35-38 |
| NCAAF | 2021/10/23 23:30 | Ohio State v Indiana | L | 54-7 |
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | L | 20-15 |
| NCAAF | 2021/10/02 23:30 | Indiana v Penn State | L | 0-24 |
Away History
| NCAAF Bowl Games | 2021/12/31 00:00 | Pittsburgh v Michigan State | W | 21-31 |
| NCAAF | 2021/11/27 20:30 | Penn State v Michigan State | W | 27-30 |
| NCAAF | 2021/11/20 17:00 | Michigan State v Ohio State | L | 7-56 |
| NCAAF | 2021/11/13 21:00 | Maryland v Michigan State | W | 21-40 |
| NCAAF | 2021/11/06 19:30 | Michigan State v Purdue | L | 29-40 |
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | W | 33-37 |
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | W | 20-15 |
| NCAAF | 2021/10/09 16:00 | Michigan State v Rutgers | W | 31-13 |
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