Duke 26-28 Pittsburgh 2022-07-22 07:00
Stadium: Acrisure Stadium Round: 1
Home Manager: Mike Elko Away Manager: Pat Narduzzi
Head to Head
| NCAAF | 2021/11/06 16:00 | Pittsburgh v Duke | L | 54-29 |
| NCAAF | 2019/10/06 00:00 | Pittsburgh v Duke | L | 33-30 |
| NCAAF | 2018/10/27 19:30 | Duke v Pittsburgh | L | 45-54 |
| NCAAF | 2017/10/21 16:20 | Pittsburgh v Duke | L | 24-17 |
| NCAAF | 2016/11/19 20:00 | Duke v Pittsburgh | L | 14-56 |
| NCAAF | 2015/11/14 17:00 | Duke v Pittsburgh | L | 13-31 |
| NCAAF | 2014/11/01 16:00 | Pittsburgh v Duke | W | 48-51 |
Home History
| NCAAF | 2021/11/27 17:30 | Miami Florida v Duke | L | 47-10 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | L | 62-22 |
| NCAAF | 2021/11/13 20:30 | Duke v Virginia Tech | L | 17-48 |
| NCAAF | 2021/11/06 16:00 | Pittsburgh v Duke | L | 54-29 |
| NCAAF | 2021/10/30 20:00 | Duke v Wake Forest | L | 7-45 |
| NCAAF | 2021/10/16 16:30 | Duke v Virginia | L | 0-48 |
| NCAAF | 2021/10/09 16:30 | Georgia Tech v Duke | L | 31-27 |
| NCAAF | 2021/10/02 16:00 | Duke v North Carolina | L | 7-38 |
Away History
| NCAAF Bowl Games | 2021/12/31 00:00 | Pittsburgh v Michigan State | L | 21-31 |
| NCAAF | 2021/12/05 01:00 | Wake Forest v Pittsburgh | W | 21-45 |
| NCAAF | 2021/11/28 00:30 | Pittsburgh v Syracuse | W | 31-14 |
| NCAAF | 2021/11/20 20:30 | Virginia v Pittsburgh | W | 38-48 |
| NCAAF | 2021/11/12 00:30 | North Carolina v Pittsburgh | W | 23-30 |
| NCAAF | 2021/11/06 16:00 | Pittsburgh v Duke | W | 54-29 |
| NCAAF | 2021/10/30 16:00 | Miami Florida v Pittsburgh | L | 38-34 |
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | W | 17-27 |
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