[17] Tottenham 4-1 Southampton [16] 2022-04-12 08:00
Stadium: Tottenham Hotspur Stadium Round: 1
Referee: Andre Marriner Home Manager: Antonio Conte Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2022/02/09 19:45 | Tottenham v Southampton | L | 2-3 |
| England Premier League | 2021/12/28 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2021/04/21 17:00 | Tottenham v Southampton | W | 2-1 |
| England Premier League | 2020/09/20 11:00 | Southampton v Tottenham | W | 2-5 |
| England FA Cup | 2020/02/05 19:45 | Tottenham v Southampton | W | 3-2 |
| England FA Cup | 2020/01/25 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2020/01/01 15:00 | Southampton v Tottenham | L | 1-0 |
| England Premier League | 2019/09/28 14:00 | Tottenham v Southampton | W | 2-1 |
Home History
| England Premier League | 2022/04/09 16:30 | Aston Villa v Tottenham | W | 0-4 |
| England Premier League | 2022/04/03 15:30 | Tottenham v Newcastle | W | 5-1 |
| England Premier League | 2022/03/20 16:30 | Tottenham v West Ham | W | 3-1 |
| England Premier League | 2022/03/16 19:30 | Brighton v Tottenham | W | 0-2 |
| England Premier League | 2022/03/12 17:30 | Man Utd v Tottenham | L | 3-2 |
| England Premier League | 2022/03/07 20:00 | Tottenham v Everton | W | 5-0 |
| England FA Cup | 2022/03/01 19:55 | Middlesbrough v Tottenham | D | 0-0 |
| England Premier League | 2022/02/26 12:30 | Leeds v Tottenham | W | 0-4 |
Away History
| England Premier League | 2022/04/09 14:00 | Southampton v Chelsea | L | 0-6 |
| England Premier League | 2022/04/02 14:00 | Leeds v Southampton | D | 1-1 |
| England FA Cup | 2022/03/20 15:00 | Southampton v Man City | L | 1-4 |
| England Premier League | 2022/03/13 14:00 | Southampton v Watford | L | 1-2 |
| England Premier League | 2022/03/10 19:30 | Southampton v Newcastle | L | 1-2 |
| England Premier League | 2022/03/05 15:00 | Aston Villa v Southampton | L | 4-0 |
| England FA Cup | 2022/03/02 19:30 | Southampton v West Ham | W | 3-1 |
| England Premier League | 2022/02/25 20:00 | Southampton v Norwich | W | 2-0 |
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