| Uruguay Reserve League | 2021/12/07 19:00 | Defensor Sporting Reserves v Juventud De Las Piedras Reserves | L | 0-1 |
| Uruguay Reserve League | 2021/11/29 19:00 | Rampla Juniors Reserves v Defensor Sporting Reserves | W | 0-3 |
| Uruguay Reserve League | 2021/11/22 19:00 | Defensor Sporting Reserves v Albion FC Reserves | W | 1-0 |
| Uruguay Reserve League | 2021/10/26 18:30 | Defensor Sporting Reserves v Rampla Juniors Reserves | D | 1-1 |
| Uruguay Reserve League | 2021/09/06 18:00 | Defensor Sporting Reserves v Albion FC Reserves | D | 1-1 |
| Uruguay Reserve League | 2021/08/30 18:17 | Juventud De Las Piedras Reserves v Defensor Sporting Reserves | W | 0-1 |
| Uruguay Reserve League | 2021/08/24 18:00 | Defensor Sporting Reserves v Rampla Juniors Reserves | D | 1-1 |
| Uruguay Reserve League | 2021/08/02 18:00 | Defensor Sporting Reserves v Juventud De Las Piedras Reserves | D | 2-2 |
| Uruguay Reserve League | 2021/11/15 19:00 | Cerrito Reserves v Liverpool Montevideo Reserves | L | 1-3 |
| Uruguay Reserve League | 2021/11/09 18:30 | Deportivo Maldonado Reserves v Cerrito Reserves | L | 1-0 |
| Uruguay Reserve League | 2021/10/25 18:30 | Nacional de Montevideo Reserves v Cerrito Reserves | L | 1-0 |
| Uruguay Reserve League | 2021/10/19 18:30 | Cerrito Reserves v Villa Espanola Reserves | W | 2-1 |
| Uruguay Reserve League | 2021/10/04 18:30 | Torque Reserves v Cerrito Reserves | D | 1-1 |
| Uruguay Reserve League | 2021/09/27 18:00 | Cerrito Reserves v Penarol Reserves | L | 0-2 |
| Uruguay Reserve League | 2021/09/06 18:00 | Rentistas Reserves v Cerrito Reserves | W | 2-3 |
| Uruguay Reserve League | 2021/08/23 18:00 | Boston River Reserves v Cerrito Reserves | D | 2-2 |