Head to Head
| MLB Spring Training | 2021/03/28 20:05 | SD Padres v CLE Guardians | D | 3-3 |
| MLB Spring Training | 2021/03/11 20:10 | CLE Guardians v SD Padres | L | 4-5 |
| MLB Exhibition | 2020/02/26 20:10 | CLE Guardians v SD Padres | L | 0-8 |
| MLB Spring Training | 2019/03/18 20:05 | SD Padres v CLE Guardians | L | 3-1 |
| MLB Spring Training | 2019/03/04 20:10 | CLE Guardians v SD Padres | L | 0-8 |
| MLB Spring Training | 2018/03/22 20:05 | SD Padres v CLE Guardians | L | 7-6 |
| MLB Spring Training | 2018/03/10 20:10 | CLE Guardians v SD Padres | D | 8-8 |
| MLB | 2017/07/06 23:10 | SD Padres v CLE Guardians | W | 2-11 |
Home History
| MLB | 2021/10/03 19:05 | CLE Guardians v TEX Rangers | W | 6-0 |
| MLB | 2021/10/02 23:05 | CLE Guardians v TEX Rangers | L | 2-7 |
| MLB | 2021/10/02 00:05 | CLE Guardians v TEX Rangers | W | 9-6 |
| MLB | 2021/10/01 00:10 | CLE Guardians v KC Royals | W | 6-1 |
| MLB | 2021/09/30 00:10 | CLE Guardians v KC Royals | L | 5-10 |
| MLB | 2021/09/29 00:10 | CLE Guardians v KC Royals | L | 4-6 |
| MLB | 2021/09/27 17:10 | KC Royals v CLE Guardians | W | 3-8 |
| MLB | 2021/09/26 17:10 | CHI White Sox v CLE Guardians | L | 5-2 |
Away History
| MLB | 2021/10/03 19:05 | SD Padres v SF Giants | L | 4-11 |
| MLB | 2021/10/02 20:05 | SD Padres v SF Giants | W | 3-2 |
| MLB | 2021/10/02 01:45 | SD Padres v SF Giants | L | 0-3 |
| MLB | 2021/10/01 02:10 | SD Padres v LA Dodgers | L | 3-8 |
| MLB | 2021/09/30 02:10 | SD Padres v LA Dodgers | L | 9-11 |
| MLB | 2021/09/29 02:10 | SD Padres v LA Dodgers | L | 1-2 |
| MLB | 2021/09/26 20:10 | ATL Braves v SD Padres | L | 4-3 |
| MLB | 2021/09/25 23:15 | ATL Braves v SD Padres | L | 10-8 |
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