[15] PHI Flyers 3-4 BUF Sabres [6] 2021-12-04 05:00
Stadium: KeyBank Center
Home Manager: Mike Yeo Away Manager: Don Granato
Head to Head
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | L | 5-3 |
| NHL | 2021/03/31 23:30 | PHI Flyers v BUF Sabres | L | 1-6 |
| NHL | 2021/03/29 23:00 | PHI Flyers v BUF Sabres | W | 4-3 |
| NHL | 2021/03/10 00:00 | BUF Sabres v PHI Flyers | W | 4-5 |
| NHL | 2021/02/28 20:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/02/27 18:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/01/20 00:00 | BUF Sabres v PHI Flyers | W | 0-3 |
| NHL | 2021/01/19 00:30 | BUF Sabres v PHI Flyers | L | 6-1 |
Home History
| NHL | 2021/12/02 00:00 | PHI Flyers v NY Rangers | L | 1-4 |
| NHL | 2021/11/29 00:00 | PHI Flyers v NJ Devils | L | 2-5 |
| NHL | 2021/11/26 20:30 | CAR Hurricanes v PHI Flyers | L | 6-3 |
| NHL | 2021/11/25 00:00 | PHI Flyers v FLA Panthers | L | 1-2 |
| NHL | 2021/11/24 00:00 | PHI Flyers v TB Lightning | L | 0-4 |
| NHL | 2021/11/21 00:00 | BOS Bruins v PHI Flyers | L | 5-2 |
| NHL | 2021/11/19 00:00 | TB Lightning v PHI Flyers | L | 4-3 |
| NHL | 2021/11/17 00:00 | CGY Flames v PHI Flyers | W | 1-2 |
Away History
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
| NHL | 2021/11/30 00:00 | SEA Kraken v BUF Sabres | L | 7-4 |
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | L | 2-3 |
| NHL | 2021/11/27 00:00 | MTL Canadiens v BUF Sabres | W | 1-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | L | 7-4 |
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2021/11/19 00:00 | CGY Flames v BUF Sabres | L | 5-0 |
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