[15] PHI Flyers 3-4 BUF Sabres [6] 2021-12-22 03:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Yeo
Head to Head
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | L | 5-3 |
| NHL | 2021/03/31 23:30 | PHI Flyers v BUF Sabres | L | 1-6 |
| NHL | 2021/03/29 23:00 | PHI Flyers v BUF Sabres | W | 4-3 |
| NHL | 2021/03/10 00:00 | BUF Sabres v PHI Flyers | W | 4-5 |
| NHL | 2021/02/28 20:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/02/27 18:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/01/20 00:00 | BUF Sabres v PHI Flyers | W | 0-3 |
| NHL | 2021/01/19 00:30 | BUF Sabres v PHI Flyers | L | 6-1 |
Home History
| NHL | 2021/12/19 00:00 | OTT Senators v PHI Flyers | W | 3-4 |
| NHL | 2021/12/17 00:00 | PHI Flyers v MTL Canadiens | L | 2-3 |
| NHL | 2021/12/15 00:00 | NJ Devils v PHI Flyers | W | 1-6 |
| NHL | 2021/12/12 02:00 | PHI Flyers v ARZ Coyotes | W | 5-3 |
| NHL | 2021/12/11 03:00 | PHI Flyers v VGS Golden Knights | W | 4-3 |
| NHL | 2021/12/09 00:00 | PHI Flyers v NJ Devils | L | 0-3 |
| NHL | 2021/12/07 00:00 | COL Avalanche v PHI Flyers | L | 7-5 |
| NHL | 2021/12/05 23:00 | TB Lightning v PHI Flyers | L | 7-1 |
Away History
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | L | 2-3 |
| NHL | 2021/12/17 01:00 | BUF Sabres v MIN Wild | W | 3-2 |
| NHL | 2021/12/15 01:00 | BUF Sabres v WPG Jets | W | 4-2 |
| NHL | 2021/12/12 00:00 | WAS Capitals v BUF Sabres | L | 3-2 |
| NHL | 2021/12/11 00:00 | NY Rangers v BUF Sabres | L | 2-1 |
| NHL | 2021/12/08 00:30 | ANA Ducks v BUF Sabres | L | 2-0 |
| NHL | 2021/12/05 00:30 | BUF Sabres v CAR Hurricanes | L | 2-6 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
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