Head to Head
| Mexico Liga MX Femenil | 2021/08/24 00:00 | Leon (W) v Santos Laguna (W) | W | 1-6 |
| Mexico Liga MX Femenil | 2021/02/04 23:00 | Leon (W) v Santos Laguna (W) | L | 2-1 |
| Mexico Liga MX Femenil | 2020/09/22 00:00 | Santos Laguna (W) v Leon (W) | D | 1-1 |
| Mexico Liga MX Femenil | 2020/02/25 03:00 | Santos Laguna (W) v Leon (W) | L | 1-2 |
| Mexico Liga MX Femenil | 2019/09/24 00:00 | Leon (W) v Santos Laguna (W) | L | 2-0 |
| Mexico Liga MX Femenil | 2019/04/02 03:00 | Leon (W) v Santos Laguna (W) | L | 1-0 |
| Mexico Liga MX Femenil | 2019/02/05 01:00 | Santos Laguna (W) v Leon (W) | L | 0-1 |
| Mexico Liga MX Femenil | 2018/10/26 00:00 | Leon (W) v Santos Laguna (W) | L | 3-0 |
Home History
| Mexico Liga MX Femenil | 2021/12/06 18:00 | Atlas (W) v Santos Laguna (W) | L | 2-1 |
| Mexico Liga MX Femenil | 2021/12/04 00:00 | Santos Laguna (W) v Atlas (W) | D | 2-2 |
| Mexico Liga MX Femenil | 2021/11/22 03:00 | Santos Laguna (W) v Tigres UANL (W) | L | 0-2 |
| Mexico Liga MX Femenil | 2021/11/13 23:00 | Queretaro (W) v Santos Laguna (W) | L | 4-2 |
| Mexico Liga MX Femenil | 2021/11/09 01:00 | Pachuca (W) v Santos Laguna (W) | L | 4-0 |
| Mexico Liga MX Femenil | 2021/11/02 03:00 | Santos Laguna (W) v Atletico San Luis (W) | W | 3-1 |
| Mexico Liga MX Femenil | 2021/10/18 22:00 | Santos Laguna (W) v Unam Pumas (W) | W | 2-0 |
| Mexico Liga MX Femenil | 2021/10/09 21:00 | Toluca (W) v Santos Laguna (W) | L | 1-0 |
Away History
| Mexico Liga MX Femenil | 2021/11/20 16:00 | Club America (W) v Leon (W) | L | 4-1 |
| Mexico Liga MX Femenil | 2021/11/13 00:00 | Leon (W) v Atletico San Luis (W) | D | 0-0 |
| Mexico Liga MX Femenil | 2021/11/08 23:00 | Toluca (W) v Leon (W) | W | 0-3 |
| Mexico Liga MX Femenil | 2021/11/02 01:00 | Leon (W) v Pachuca (W) | L | 1-3 |
| Mexico Liga MX Femenil | 2021/10/18 00:00 | Leon (W) v Atlas (W) | L | 0-1 |
| Mexico Liga MX Femenil | 2021/10/09 17:00 | Cruz Azul (W) v Leon (W) | D | 0-0 |
| Mexico Liga MX Femenil | 2021/10/05 00:00 | Monterrey (W) v Leon (W) | L | 3-1 |
| Mexico Liga MX Femenil | 2021/09/28 00:00 | Leon (W) v Necaxa (W) | D | 1-1 |
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