Stadium: Jack Breslin Students Events Center
Home Manager: Tom Izzo Away Manager: Brad Underwood
| NCAAB | 2021/02/24 00:00 | Illinois v Michigan State | L | 72-81 |
| NCAAB | 2020/02/12 02:00 | Michigan State v Illinois | L | 70-69 |
| NCAAB | 2020/01/03 01:00 | Illinois v Michigan State | L | 56-76 |
| NCAAB | 2019/02/06 00:00 | Michigan State v Illinois | W | 74-79 |
| NCAAB | 2018/02/21 00:00 | Illinois v Michigan State | L | 61-81 |
| NCAAB | 2018/01/23 02:00 | Michigan State v Illinois | L | 87-74 |
| NCAAB | 2017/03/02 02:00 | Michigan State v Illinois | W | 70-73 |
| NCAAB | 2016/01/08 02:00 | Michigan State v Illinois | L | 79-54 |
| NCAAB | 2021/12/23 02:00 | Illinois v Missouri | W | 88-63 |
| NCAAB | 2021/12/18 18:00 | St Francis PA v Illinois | W | 48-106 |
| NCAAB | 2021/12/11 22:00 | Arizona v Illinois | L | 83-79 |
| NCAAB | 2021/12/07 00:00 | Illinois v Iowa | W | 87-83 |
| NCAAB | 2021/12/04 00:00 | Rutgers v Illinois | W | 51-86 |
| NCAAB | 2021/11/30 02:00 | Notre Dame v Illinois | W | 72-82 |
| NCAAB | 2021/11/27 01:00 | UT-Rio Grande Valley v Illinois | W | 85-94 |
| NCAAB | 2021/11/24 00:00 | Illinois v Kansas State | W | 72-64 |
| NCAAB | 2021/12/22 00:30 | Michigan State v Oakland | W | 90-78 |
| NCAAB | 2021/12/11 19:00 | Penn State v Michigan State | W | 64-80 |
| NCAAB | 2021/12/09 02:00 | Michigan State v Minnesota | W | 75-67 |
| NCAAB | 2021/12/04 22:00 | Toledo v Michigan State | W | 68-81 |
| NCAAB | 2021/12/02 00:15 | Louisville v Michigan State | W | 64-73 |
| NCAAB | 2021/11/26 16:00 | Baylor Bears v Michigan State | L | 75-58 |
| NCAAB | 2021/11/25 17:00 | Connecticut v Michigan State | W | 60-64 |
| NCAAB | 2021/11/24 15:00 | Loyola Chicago v Michigan State | W | 61-63 |