Stadium: Banterra Center
Home Manager: Bryan Mullins Away Manager: Darian DeVries
| NCAAB | 2021/01/05 00:00 | Southern Illinois v Drake | W | 55-86 |
| NCAAB | 2021/01/03 23:00 | Southern Illinois v Drake | W | 55-73 |
| NCAAB | 2020/02/01 23:00 | Southern Illinois v Drake | L | 79-72 |
| NCAAB | 2020/01/19 21:00 | Drake v Southern Illinois | L | 49-66 |
| NCAAB | 2019/02/13 01:00 | Drake v Southern Illinois | W | 72-69 |
| NCAAB | 2019/01/09 01:00 | Southern Illinois v Drake | W | 70-82 |
| NCAAB | 2018/01/31 01:00 | Southern Illinois v Drake | L | 78-67 |
| NCAAB | 2017/12/31 21:00 | Drake v Southern Illinois | W | 70-67 |
| NCAAB | 2021/03/20 20:35 | Drake v USC Trojans | L | 56-72 |
| NCAAB | 2021/03/18 22:27 | Drake v Wichita State | W | 53-52 |
| NCAAB | 2021/03/07 19:00 | Drake v Loyola Chicago | L | 65-75 |
| NCAAB | 2021/03/06 21:00 | Missouri State v Drake | W | 69-71 |
| NCAAB | 2021/02/28 00:00 | Drake v Bradley | L | 61-67 |
| NCAAB | 2021/02/27 00:00 | Drake v Bradley | W | 80-71 |
| NCAAB | 2021/02/23 00:00 | Evansville v Drake | W | 63-74 |
| NCAAB | 2021/02/21 21:00 | Evansville v Drake | W | 71-85 |
| NCAAB | 2021/03/05 17:00 | Southern Illinois v Loyola Chicago | L | 49-73 |
| NCAAB | 2021/03/04 23:00 | Southern Illinois v Bradley | W | 73-63 |
| NCAAB | 2021/02/27 23:00 | Southern Illinois v Loyola Chicago | L | 58-65 |
| NCAAB | 2021/02/27 02:00 | Southern Illinois v Loyola Chicago | L | 52-60 |
| NCAAB | 2021/02/23 00:00 | Valparaiso v Southern Illinois | W | 64-67 |
| NCAAB | 2021/02/21 22:00 | Valparaiso v Southern Illinois | L | 66-65 |
| NCAAB | 2021/02/18 02:15 | Missouri State v Southern Illinois | L | 68-53 |
| NCAAB | 2021/02/14 21:00 | Illinois St v Southern Illinois | W | 49-59 |