Stadium: Edmunds Center
Home Manager: Pat Kelsey Away Manager: Donnie Jones
| NCAAB | 2021/12/01 00:30 | Tulane v Coll of Charleston | W | 77-81 |
| NCAAB | 2021/11/27 21:00 | Coll of Charleston v Chattanooga | W | 68-66 |
| NCAAB | 2021/11/23 01:00 | Coll of Charleston v Oklahoma State | L | 66-96 |
| NCAAB | 2021/11/17 01:30 | North Carolina v Coll of Charleston | L | 94-83 |
| NCAAB | 2021/11/13 22:00 | Loyola Maryland v Coll of Charleston | W | 72-79 |
| NCAAB | 2021/11/13 00:30 | Lipscomb v Coll of Charleston | W | 77-86 |
| NCAAB | 2021/11/12 00:00 | South Carolina State v Coll of Charleston | W | 74-106 |
| NCAAB | 2021/03/08 02:30 | Drexel v Coll of Charleston | L | 80-75 |
| NCAAB | 2021/12/02 00:00 | Stetson v Florida Atlantic | L | 73-83 |
| NCAAB | 2021/11/27 20:00 | Campbell v Stetson | L | 60-58 |
| NCAAB | 2021/11/20 01:00 | Stetson v Lamar | W | 60-59 |
| NCAAB | 2021/11/18 00:00 | Stetson v Miami Ohio | L | 65-80 |
| NCAAB | 2021/11/13 00:30 | Stetson v Georgia Tech | L | 52-77 |
| NCAAB | 2021/11/10 00:30 | Stetson v Florida Memorial | W | 74-67 |
| CBI | 2021/03/23 21:30 | Stetson v Coastal Carolina | L | 72-77 |
| CBI | 2021/03/22 15:30 | Stetson v Bowling Green | W | 53-52 |