Stadium: Ellis T. Johnson Arena
Home Manager: Samantha Quigley Smith Away Manager: Cayla Petree
| WNCAAB | 2021/01/19 23:00 | Morehead State (W) v SIU Edwardsville (W) | L | 53-47 |
| WNCAAB | 2021/01/16 18:30 | SIU Edwardsville (W) v Morehead State (W) | L | 53-63 |
| WNCAAB | 2020/02/06 23:30 | Morehead State (W) v SIU Edwardsville (W) | L | 63-55 |
| WNCAAB | 2020/01/09 22:00 | Morehead State (W) v SIU Edwardsville (W) | L | 75-69 |
| WNCAAB | 2019/01/31 17:00 | SIU Edwardsville (W) v Morehead State (W) | L | 67-73 |
| WNCAAB | 2018/01/06 19:00 | Morehead State (W) v SIU Edwardsville (W) | W | 51-66 |
| WNCAAB | 2021/12/22 23:30 | Arkansas State (W) v SIU Edwardsville (W) | L | 74-71 |
| WNCAAB | 2021/12/19 21:30 | Toledo (W) v SIU Edwardsville (W) | L | 66-57 |
| WNCAAB | 2021/12/11 19:00 | Illinois State Women v SIU Edwardsville (W) | L | 80-71 |
| WNCAAB | 2021/12/10 01:00 | St Louis Women v SIU Edwardsville (W) | W | 57-63 |
| WNCAAB | 2021/12/08 00:00 | Western Illinois Women v SIU Edwardsville (W) | L | 96-93 |
| WNCAAB | 2021/12/03 01:00 | SIU Edwardsville (W) v Missouri (W) | L | 46-79 |
| WNCAAB | 2021/11/28 20:00 | Purdue Fort Wayne Women v SIU Edwardsville (W) | W | 56-68 |
| WNCAAB | 2021/11/23 17:00 | SIU Edwardsville (W) v Butler (W) | W | 87-74 |
| WNCAAB | 2021/12/19 18:00 | Valparaiso Women v Morehead State (W) | L | 65-57 |
| WNCAAB | 2021/12/18 19:00 | Morehead State (W) v USC Upstate (W) | L | 52-66 |
| WNCAAB | 2021/12/15 22:00 | Morehead State (W) v Eastern Kentucky (W) | L | 43-66 |
| WNCAAB | 2021/12/11 19:00 | Morehead State (W) v Evansville (W) | L | 49-79 |
| WNCAAB | 2021/12/01 01:00 | Morehead State (W) v Baylor (W) | L | 28-73 |
| WNCAAB | 2021/11/27 19:00 | Morehead State (W) v Bellarmine (W) | L | 61-68 |
| WNCAAB | 2021/11/24 21:00 | Morehead State (W) v Robert Morris (W) | L | 45-69 |
| WNCAAB | 2021/11/21 23:00 | Morehead State (W) v Midway Women | W | 72-53 |