Stadium: Brentford Community Stadium Round: 21
Referee: Wayne Barnes
| Premier Rugby Cup | 2021/11/13 15:30 | Northampton v London Irish | W | 26-36 |
| Prem Rugby | 2021/10/02 13:00 | Northampton v London Irish | L | 23-21 |
| Prem Rugby | 2021/04/16 18:45 | Northampton v London Irish | L | 44-26 |
| Prem Rugby | 2020/08/22 13:00 | London Irish v Northampton | L | 3-27 |
| Prem Rugby | 2020/01/24 19:45 | Northampton v London Irish | W | 16-20 |
| Prem Rugby | 2018/02/17 15:00 | Northampton v London Irish | L | 25-17 |
| Prem Rugby | 2017/09/24 14:00 | London Irish v Northampton | L | 25-40 |
| Prem Rugby | 2016/02/13 15:00 | Northampton v London Irish | L | 35-7 |
| Prem Rugby | 2022/02/11 19:45 | Bristol v London Irish | W | 32-49 |
| Prem Rugby | 2022/02/04 19:45 | Gloucester v London Irish | L | 24-7 |
| Prem Rugby | 2022/01/29 15:00 | London Irish v Exeter Chiefs | W | 18-14 |
| European Rugby Challenge Cup | 2022/01/23 15:15 | Saracens v London Irish | L | 45-24 |
| European Rugby Challenge Cup | 2022/01/15 15:15 | London Irish v Edinburgh | W | 21-20 |
| Prem Rugby | 2021/12/26 15:00 | Wasps v London Irish | L | 38-30 |
| European Rugby Challenge Cup | 2021/12/19 15:15 | London Irish v Brive | D | 0-0 |
| European Rugby Challenge Cup | 2021/12/11 20:00 | Pau v London Irish | W | 17-33 |
| Prem Rugby | 2022/02/11 19:45 | Leicester v Northampton | L | 35-20 |
| Prem Rugby | 2022/01/29 15:00 | Worcester Warriors v Northampton | W | 13-29 |
| European Rugby Champions Cup | 2022/01/23 15:15 | Racing 92 v Northampton | L | 28-0 |
| European Rugby Champions Cup | 2022/01/16 15:15 | Northampton v Ulster | L | 20-24 |
| Prem Rugby | 2022/01/08 15:00 | Newcastle Red Bulls v Northampton | W | 8-44 |
| Prem Rugby | 2022/01/02 15:00 | Northampton v Saracens | L | 6-30 |
| Prem Rugby | 2021/12/27 17:00 | Harlequins v Northampton | L | 41-27 |
| European Rugby Champions Cup | 2021/12/17 20:00 | Ulster v Northampton | L | 27-22 |