Clemson 30-0 South Carolina 2021-09-20 06:30
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Shane Beamer
Head to Head
| NCAAF | 2019/11/30 17:00 | Clemson v South Carolina | W | 38-3 |
| NCAAF | 2018/11/25 00:00 | South Carolina v Clemson | W | 35-56 |
| NCAAF | 2017/11/26 00:30 | Clemson v South Carolina | W | 34-10 |
| NCAAF | 2016/11/27 00:30 | South Carolina v Clemson | W | 7-56 |
| NCAAF | 2015/11/28 17:00 | South Carolina v Clemson | W | 32-37 |
| NCAAF | 2014/11/29 17:00 | Clemson v South Carolina | W | 35-17 |
| NCAAF | 2012/11/24 12:00 | Clemson v South Carolina | L | 17-27 |
| NCAAF | 2011/11/26 12:00 | South Carolina v Clemson | L | 34-13 |
Home History
| NCAAF | 2021/09/18 19:30 | Georgia Tech v Clemson | W | 8-14 |
| NCAAF | 2021/09/11 21:00 | South Carolina State v Clemson | W | 3-49 |
| NCAAF | 2021/09/04 23:30 | Georgia v Clemson | L | 10-3 |
| NCAAF | 2021/01/02 01:00 | Ohio State v Clemson | L | 49-28 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | W | 34-10 |
| NCAAF | 2020/12/06 00:30 | Clemson v Virginia Tech | W | 45-10 |
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | W | 17-52 |
| NCAAF | 2020/11/08 00:30 | Clemson v Notre Dame | L | 40-47 |
Away History
| NCAAF | 2021/09/18 23:00 | South Carolina v Georgia | L | 13-40 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | W | 20-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | W | 0-46 |
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | L | 18-41 |
| NCAAF | 2020/11/29 00:30 | Georgia v South Carolina | L | 45-16 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | L | 17-10 |
| NCAAF | 2020/11/15 00:30 | South Carolina v Mississippi | L | 42-59 |
| NCAAF | 2020/11/08 00:00 | Texas A&M v South Carolina | L | 48-3 |
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