Stadium: Lotto Park Round: 28
Referee: Bram Van Driessche Home Manager: Vincent Kompany Away Manager: Bernd Storck
| Belgium First Division A | 2021/08/29 16:30 | Genk v Anderlecht | L | 1-0 |
| Belgium First Division A | 2021/05/15 18:45 | Anderlecht v Genk | L | 1-2 |
| Belgium First Division A | 2021/05/12 18:45 | Genk v Anderlecht | D | 1-1 |
| Belgium Cup | 2021/03/14 19:45 | Anderlecht v Genk | L | 1-2 |
| Belgium First Division A | 2021/02/07 17:15 | Genk v Anderlecht | W | 1-2 |
| Belgium First Division A | 2020/12/11 19:45 | Anderlecht v Genk | W | 1-0 |
| Belgium First Division A | 2019/12/22 19:00 | Anderlecht v Genk | W | 2-0 |
| Belgium First Division A | 2019/08/23 18:30 | Genk v Anderlecht | L | 1-0 |
| Belgium First Division A | 2021/09/26 16:30 | KV Oostende v Anderlecht | D | 2-2 |
| Belgium First Division A | 2021/09/23 18:45 | Anderlecht v Gent | D | 1-1 |
| Belgium First Division A | 2021/09/19 16:30 | Standard Liege v Anderlecht | W | 0-1 |
| Belgium First Division A | 2021/09/12 11:30 | Anderlecht v KV Mechelen | W | 7-2 |
| Belgium First Division A | 2021/08/29 16:30 | Genk v Anderlecht | L | 1-0 |
| UEFA Conference League Qualifying | 2021/08/26 17:00 | Vitesse v Anderlecht | L | 2-1 |
| UEFA Conference League Qualifying | 2021/08/19 18:00 | Anderlecht v Vitesse | D | 3-3 |
| Belgium First Division A | 2021/08/15 16:30 | Cercle Brugge v Anderlecht | W | 1-2 |
| Belgium First Division A | 2021/09/26 19:00 | Genk v Seraing United | W | 3-0 |
| Belgium First Division A | 2021/09/22 18:45 | Antwerp v Genk | L | 4-2 |
| Belgium First Division A | 2021/09/19 11:30 | Sint-Truidense v Genk | W | 1-2 |
| UEFA Europa League | 2021/09/16 16:45 | Rapid Vienna v Genk | W | 0-1 |
| Belgium First Division A | 2021/09/12 19:00 | Genk v Union Saint Gilloise | D | 1-1 |
| Belgium First Division A | 2021/08/29 16:30 | Genk v Anderlecht | W | 1-0 |
| Belgium First Division A | 2021/08/14 18:45 | Genk v OH Leuven | W | 4-0 |
| UEFA Champions League Qualifying | 2021/08/10 17:30 | Shakhtar Donetsk v Genk | L | 2-1 |