[9] John Isner 1-6,4-6 Roger Federer [5] 2019-03-12 23:00
Stadium: Stadium Round: 29 Ground: Hardcourt outdoor
Head to Head
| Laver Cup | 2018/09/23 19:00 | Roger Federer v John Isner | 6-7,7-6,10-7 |
| Laver Cup | 2018/09/23 18:30 | Roger Federer v John Isner | 6-7,7-6,1-0 |
| US Open | 2015/09/08 01:00 | John Isner v Roger Federer | 6-7,6-7,5-7 |
Home History
| ATP Indian Wells | 2019/03/12 21:20 | John Isner v Guido Pella | 6-3,6-4 |
| ATP Indian Wells | 2019/03/10 23:15 | John Isner v Alexei Popyrin | 6-0,6-2 |
| ATP Acapulco | 2019/03/02 04:30 | Nick Kyrgios v John Isner | 7-5,5-7,7-6 |
| ATP Acapulco | 2019/03/01 05:10 | John Isner v John Millman | 7-6,6-7,7-6 |
| ATP Acapulco | 2019/02/27 22:00 | John Isner v Sam Querrey | 6-4,6-4 |
| ATP Acapulco | 2019/02/26 22:00 | John Isner v Adrian Mannarino | 6-3,4-6,6-3 |
| ATP Delray Beach | 2019/02/23 20:00 | Daniel Evans v John Isner | 3-6,6-2,6-3 |
| ATP Delray Beach | 2019/02/22 19:30 | Adrian Mannarino v John Isner | 6-7,4-6 |
Away History
| ATP Indian Wells | 2019/03/10 20:05 | Peter Gojowczyk v Roger Federer | 1-6,5-7 |
| ATP Dubai | 2019/03/02 15:00 | Stefanos Tsitsipas v Roger Federer | 4-6,4-6 |
| ATP Dubai | 2019/03/01 16:20 | Borna Coric v Roger Federer | 2-6,2-6 |
| ATP Dubai | 2019/02/28 15:55 | Marton Fucsovics v Roger Federer | 6-7,4-6 |
| ATP Dubai | 2019/02/27 15:00 | Fernando Verdasco v Roger Federer | 3-6,6-3,3-6 |
| ATP Dubai | 2019/02/25 15:00 | Philipp Kohlschreiber v Roger Federer | 4-6,6-3,1-6 |
| Australian Open | 2019/01/20 08:00 | Stefanos Tsitsipas v Roger Federer | 6-7,7-6,7-5,7-6 |
| Australian Open | 2019/01/18 02:00 | Taylor Fritz v Roger Federer | 2-6,5-7,2-6 |
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