Head to Head
| Mexico Liga MX | 2025/02/15 03:00 | Mazatlan FC v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2024/10/26 01:00 | Santos Laguna v Mazatlan FC | D | 0-0 |
| Mexico Liga MX | 2024/02/26 00:00 | Santos Laguna v Mazatlan FC | L | 1-0 |
| Mexico Liga MX | 2023/11/24 03:10 | Santos Laguna v Mazatlan FC | L | 2-1 |
| Mexico Liga MX | 2023/11/02 03:00 | Mazatlan FC v Santos Laguna | W | 3-1 |
| Mexico Liga MX | 2023/01/21 03:00 | Mazatlan FC v Santos Laguna | L | 1-2 |
| Club Friendly List | 2022/12/24 03:00 | Mazatlan FC v Santos Laguna | L | 2-3 |
| Mexico Liga MX | 2022/10/02 23:05 | Santos Laguna v Mazatlan FC | L | 3-0 |
Home History
| America Friendlies | 2025/07/04 00:00 | Mazatlan FC v Newell's | W | 1-0 |
| Mexico Liga MX | 2025/04/19 23:00 | Club America v Mazatlan FC | L | 5-0 |
| Mexico Liga MX | 2025/04/17 03:00 | Mazatlan FC v Tijuana | L | 0-2 |
| Mexico Liga MX | 2025/04/12 03:05 | Mazatlan FC v Chivas Guadalajara | D | 1-1 |
| Mexico Liga MX | 2025/04/06 01:00 | Atletico San Luis v Mazatlan FC | L | 2-1 |
| Mexico Liga MX | 2025/03/29 03:00 | Mazatlan FC v Atlas | W | 3-2 |
| Mexico Liga MX | 2025/03/15 01:00 | Queretaro v Mazatlan FC | L | 1-0 |
| Mexico Liga MX | 2025/03/09 01:00 | Pachuca v Mazatlan FC | D | 1-1 |
Away History
| America Friendlies | 2025/06/29 22:00 | Cruz Azul v Santos Laguna | L | 2-0 |
| America Friendlies | 2025/06/28 02:30 | Chivas Guadalajara v Santos Laguna | L | 3-1 |
| Mexico Liga MX | 2025/04/20 23:00 | Santos Laguna v Tijuana | L | 0-4 |
| Mexico Liga MX | 2025/04/17 03:05 | Unam Pumas v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2025/04/13 23:00 | Santos Laguna v Queretaro | L | 1-2 |
| Mexico Liga MX | 2025/04/07 00:00 | Toluca v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2025/03/30 23:00 | Santos Laguna v Atletico San Luis | L | 2-3 |
| Mexico Liga MX | 2025/03/15 23:00 | Tigres UANL v Santos Laguna | L | 3-0 |
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