Stadium: State Farm Stadium Round: 18
Home Manager: Kyle Shanahan Away Manager: Jonathan Gannon
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 3 | 14 | 17 | 7 | 0 | 24 |
| 3 | 17 | 20 | 6 | 21 | 47 |
| SF 49ers | ARZ Cardinals |
| Lineup | |
|---|---|
| 6 - DB - Malik Mustapha | Isaiah Adams - OL - 74 |
| 4 - K - Jake Moody | Owen Pappoe - Left back - 44 |
| 62 - OL - Austen Pleasants | Garrett Williams - Center back - 21 |
| 92 - DT - Jordan Elliott | Starling Thomas V - Center back - 24 |
| 68 - OL - Colton McKivitz | Clayton Tune - QB - 15 |
| 46 - LS - Taybor Pepper | Chad Ryland - K - 38 |
| 27 - SAF - Ji'Ayir Brown | Trey McBride - TE - 85 |
| 94 - DE - Yetur Gross-Matos | Jon Gaines II - OL - 71 |
| 61 - OL - Matt Hennessy | Christian Jones - OL - 75 |
| 75 - OT - Charlie Heck | Dante Stills - DL - 55 |
| 77 - OL - Dominick Puni | Xavier Thomas - DL - 54 |
| 44 - FB - Kyle Juszczyk | DeeJay Dallas - ATH - 20 |
| 35 - Center back - Nick McCloud | Jalen Thompson - SAF - 34 |
| 40 - Pivot - Pat O'Donnell | Sean Murphy-Bunting - DB - 23 |
| 43 - SAF - Tashaun Gipson | Trystan Colon - OL - 63 |
| 18 - WR - Chris Conley | Elijah Higgins - WR - 84 |
| 56 - Left back - Leonard Floyd | Xavier Weaver - WR - 89 |
| 99 - DT - Maliek Collins | Roy Lopez - DT - 98 |
| 64 - OL - Jake Brendel | Baron Browning - Left back - 5 |
| 69 - DL - Evan Anderson | Zaven Collins - Left back - 25 |
| 81 - WR - Trent Taylor | Khyiris Tonga - DT - 95 |
| 91 - DT - Sam Okuayinonu | Michael Carter - Right back - 22 |
| 9 - FB - Brayden Willis | Milo Eifler - Left back - 48 |
| 54 - Left back - Fred Warner | Naquan Jones - DT - 96 |
| 47 - Left back - DaShaun White | Marvin Harrison Jr. - WR - 18 |
| 88 - TE - Jake Tonges | Tip Reiman - TE - 87 |
| 63 - OL - Nick Zakelj | Julian Okwara - DE - 58 |
| 33 - Center back - Rock Ya-Sin | Max Melton - DB - 16 |
| 93 - DL - Kalia Davis | Kei'Trel Clark - Center back - 13 |
| 22 - DB - Isaac Yiadom | Dadrion Taylor-Demerson - DB - 42 |
| 32 - Right back - Patrick Taylor | Darius Robinson - DL - 56 |
| 15 - WR - Jauan Jennings | L.J. Collier - DE - 91 |
| 31 - Right back - Isaac Guerendo | Kyler Murray - QB - 1 |
| 29 - SAF - Talanoa Hufanga | Nick Leverett - OL - 50 |
| 7 - Center back - Charvarius Ward | Evan Brown - OL - 63 |
| 19 - WR - Jacob Cowing | Kyzir White - SAF - 7 |
| 85 - TE - George Kittle | Andre Chachere - Center back - 36 |
| 48 - Left back - Tatum Bethune | Zach Pascal - WR - |
| 5 - QB - Joshua Dobbs | Michael Palardy - K - 10 |
| 82 - TE - Eric Saubert | Krys Barnes - Left back - 51 |
| 41 - SAF - Jalen Graham | Zay Jones - WR - 17 |
| 1 - WR - Ricky Pearsall | Tony Jones - Right back - 37 |
| 53 - Left back - Dee Winters | Aaron Brewer - LS - 46 |
| 58 - DL - Alex Barrett | Budda Baker - DB - 3 |
| - DB - Renardo Green | Greg Dortch - WR - 4 |
| 97 - DL - Nick Bosa | Mack Wilson - Left back - 2 |
| Substitutes | |