Stadium: Highmark Stadium Round: 2
Home Manager: Josh McDaniels Away Manager: Sean McDermott
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 3 | 10 | 0 | 0 | 10 |
| 7 | 14 | 21 | 7 | 10 | 38 |
| LV Raiders | BUF Bills |
| Lineup | |
|---|---|
| 1 - WR - Tre Tucker | Spencer Brown - OT - 79 |
| 61 - OL - Jordan Meredith | Dawson Knox - TE - 88 |
| 5 - SAF - Divine Deablo | Taylor Rapp - DB - 9 |
| 24 - DB - Marcus Peters | Ed Oliver - DT - 91 |
| 45 - FB - Jakob Johnson | Reggie Gilliam - TE - 41 |
| 95 - DT - John Jenkins | Poona Ford - DT - 98 |
| 23 - DB - David Long Jr. | Kyle Allen - QB - 9 |
| 39 - Center back - Nate Hobbs | Ryan Bates - OL - 71 |
| 17 - WR - Davante Adams | Damien Harris - Right back - 22 |
| 22 - Right back - Ameer Abdullah | Tyrel Dodson - Left back - 25 |
| 21 - Center back - Amik Robertson | Josh Allen - QB - 17 |
| 34 - Right back - Brandon Bolden | Trent Sherfield - WR - 16 |
| 83 - WR - Kristian Wilkerson | Ryan Van Demark - OL - 74 |
| - DB - Jakorian Bennett | Cam Lewis - Center back - 39 |
| 93 - DL - Byron Young | Terrel Bernard - Left back - 8 |
| 25 - SAF - Trevon Moehrig | James Cook - Right back - 4 |
| 80 - TE - Jesper Horsted | Gregory Rousseau - DE - 50 |
| 51 - DE - Malcolm Koonce | Tyler Bass - K - 2 |
| 87 - TE - Michael Mayer | Gabriel Davis - WR - 13 |
| 9 - DL - Tyree Wilson | Dane Jackson - Center back - 30 |
| 10 - QB - Jimmy Garoppolo | David Edwards - OL - 76 |
| 8 - Right back - Josh Jacobs | Deonte Harty - WR - 11 |
| 96 - DL - Isaac Rochell | Connor McGovern - OL - 66 |
| 72 - OL - Jermaine Eluemunor | Quintin Morris - TE - 85 |
| 6 - Pivot - A.J. Cole | O'Cyrus Torrence - Guard - 64 |
| 69 - DL - Adam Butler | Dorian Williams - Left back - 42 |
| 59 - DB - Luke Masterson | Dalton Kincaid - TE - 86 |
| 68 - OL - Andre James | Christian Benford - DB - 47 |
| 33 - SAF - Roderic Teamer | Khalil Shakir - WR - 10 |
| 74 - OL - Kolton Miller | Siran Neal - Center back - 33 |
| 98 - DL - Maxx Crosby | Taron Johnson - Center back - 7 |
| 36 - Left back - Curtis Bolton | Tre'Davious White - Center back - 27 |
| 13 - WR - Hunter Renfrow | Mitch Morse - OL - 60 |
| 70 - OG - Greg Van Roten | Micah Hyde - Center back - 23 |
| 3 - Right back - Zamir White | Reid Ferguson - LS - 69 |
| 20 - SAF - Isaiah Pola-Mao | Daquan Jones - DT - 92 |
| 66 - OL - Dylan Parham | Tyler Matakevich - Left back - 44 |
| 1 - SS - Marcus Epps | Leonard Floyd - Left back - 56 |
| 77 - OL - Thayer Munford Jr. | Jordan Phillips - DT - 97 |
| 8 - K - Daniel Carlson | Shaq Lawson - DE - 90 |
| 50 - - Jacob Bobenmoyer | A.J. Epenesa - DE - 57 |
| 41 - Left back - Robert Spillane | Stefon Diggs - WR - 14 |
| 91 - DL - Bilal Nichols | Sam Martin - Pivot - 8 |
| 3 - WR - DeAndre Carter | Jordan Poyer - Center back - 21 |
| 81 - TE - Austin Hooper | Latavius Murray - Right back - 28 |
| 90 - DL - Jerry Tillery | Dion Dawkins - OL - 73 |
| Substitutes | |