Stadium: Highmark Stadium Round: 1
Home Manager: Bill Belichick Away Manager: Sean McDermott
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 7 | 14 | 3 | 6 | 23 |
| 7 | 7 | 14 | 14 | 7 | 35 |
| NE Patriots | BUF Bills |
| Lineup | |
|---|---|
| 11 - WR - Tyquan Thornton | Spencer Brown - OT - 79 |
| 8 - Left back - Ja'Whaun Bentley | Tremaine Edmunds - Left back - 49 |
| 35 - Right back - Pierre Strong Jr. | Josh Allen - QB - 17 |
| 90 - DT - Christian Barmore | Devin Singletary - Right back - 26 |
| 15 - WR - Nelson Agholor | Nyheim Hines - Right back - |
| 10 - QB - Mac Jones | Cam Lewis - Center back - 39 |
| 25 - Center back - Marcus Jones | Siran Neal - Center back - 33 |
| 6 - K - Nick Folk | Taron Johnson - Center back - 7 |
| 18 - WR - Matt Slater | Tim Settle - DT - 99 |
| 27 - DB - Myles Bryant | Isaiah McKenzie - WR - 6 |
| 23 - DB - Kyle Dugger | Matt Milano - Left back - 58 |
| 71 - OL - Michael Onwenu | Tyrel Dodson - Left back - 25 |
| 32 - Center back - Devin McCourty | Dion Dawkins - OL - 73 |
| 33 - Left back - Anfernee Jennings | Tre'Davious White - Center back - 27 |
| 93 - DL - Lawrence Guy | Jaquan Johnson - DB - 4 |
| 55 - Left back - Josh Uche | Ryan Bates - OL - 71 |
| 97 - DE - Damarcus Mitchell | Boogie Basham - DE - 55 |
| 38 - Right back - Rhamondre Stevenson | Gregory Rousseau - DE - 50 |
| 95 - DL - Daniel Ekuale | Tyler Bass - K - 2 |
| 65 - OL - James Ferentz | Gabriel Davis - WR - 13 |
| 48 - Left back - Jahlani Tavai | A.J. Epenesa - DE - 57 |
| 17 - K - Michael Palardy | Kaiir Elam - Center back - 24 |
| 69 - OL - Cole Strange | Khalil Shakir - WR - 10 |
| 84 - WR - Kendrick Bourne | James Cook - Right back - 4 |
| 43 - Left back - Calvin Munson | Terrel Bernard - Left back - 8 |
| 21 - SAF - Adrian Phillips | Quintin Morris - TE - 85 |
| 75 - OL - Conor McDermott | Dawson Knox - TE - 88 |
| 91 - DL - Deatrich Wise Jr. | Ed Oliver - DT - 91 |
| 85 - TE - Hunter Henry | Reggie Gilliam - TE - 41 |
| 5 - DB - Jabrill Peppers | Greg Van Roten - OG - 75 |
| 31 - DB - Jonathan Jones | Bobby Hart - OT - 68 |
| 60 - Center - David Andrews | Jordan Phillips - DT - 52 |
| 46 - - Tucker Addington | David Quessenberry - OT - 77 |
| 77 - OT - Trent Brown | A.J. Klein - Left back - 52 |
| 87 - TE - Matt Sokol | Dean Marlowe - SAF - 31 |
| 1 - WR - Devante Parker | Rodger Saffold - OT - 76 |
| 39 - DB - Tae Hayes | Sam Martin - Pivot - 8 |
| 92 - DT - Davon Godchaux | Stefon Diggs - WR - 14 |
| 3 - Left back - Mack Wilson | Mitch Morse - OL - 60 |
| 37 - Right back - Damien Harris | John Brown - WR - 16 |
| 50 - Left back - Raekwon McMillan | Daquan Jones - DT - 92 |
| 98 - DL - Carl Davis | Jordan Poyer - Center back - 21 |
| 16 - WR - Jakobi Meyers | Reid Ferguson - LS - 69 |
| 44 - WR - Raleigh Webb | Dane Jackson - Center back - 30 |
| 72 - OL - Yodny Cajuste | Shaq Lawson - DE - 90 |
| 9 - Left back - Matt Judon | Taiwan Jones - Right back - 25 |
| Substitutes | |