Stadium: NRG Stadium Round: 1
Home Manager: Brandon Staley Away Manager: Lovie Smith
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 20 | 27 | 0 | 7 | 34 |
| 0 | 7 | 7 | 7 | 10 | 24 |
| LA Chargers | HOU Texans |
| Lineup | |
|---|---|
| 82 - WR - Richard Rodgers | Roy Lopez - DT - 91 |
| 6 - K - Dustin Hopkins | M.J. Stewart - Center back - 29 |
| 32 - SAF - Alohi Gilman | Grayland Arnold - Center back - 35 |
| 8 - Left back - Kyle Van Noy | Ogbonnia Okoronkwo - Left back - 45 |
| 9 - Left back - Kenneth Murray Jr. | Tytus Howard - OL - 71 |
| 25 - Right back - Joshua Kelley | Jordan Akins - TE - 88 |
| 59 - OLB - Derrek Tuszka | Rasheem Green - DT - 92 |
| 26 - Center back - Asante Samuel Jr. | Scott Quessenberry - OL - 54 |
| 33 - DB - Deane Leonard | Tremon Smith - Center back - 11 |
| 40 - Right back - Zander Horvath | Dare Ogunbowale - Right back - 33 |
| 36 - DB - Ja'Sir Taylor | Kurt Hinish - DL - 93 |
| 68 - OL - Jamaree Salyer | Cameron Johnston - Pivot - 11 |
| 83 - WR - Michael Bandy | Desmond King - DB - 25 |
| 88 - TE - Tre McKitty | Mason Schreck - TE - 86 |
| 5 - WR - Josh Palmer | Jalen Pitre - SAF - 5 |
| 57 - Left back - Amen Ogbongbemiga | Garret Wallow - Left back - 32 |
| 94 - DE - Chris Rumph | Davis Mills - QB - 10 |
| 47 - - Josh Harris | Jimmy Morrissey - Center - 79 |
| 10 - QB - Justin Herbert | Jonathan Greenard - Left back - 52 |
| 31 - Left back - Nick Niemann | Charlie Heck - OT - 67 |
| 79 - OT - Trey Pipkins III | Tyler Johnson - WR - 14 |
| 11 - WR - Jason Moore | Nico Collins - WR - 12 |
| 76 - Center - Will Clapp | Blake Cashman - Left back - 53 |
| 49 - Left back - Drue Tranquill | Kenyon Green - OL - 59 |
| 7 - TE - Gerald Everett | Derek Stingley Jr. - Center back - 24 |
| 99 - DL - Jerry Tillery | Jonathan Owens - SAF - 36 |
| 98 - DT - Austin Johnson | Thomas Booker IV - DE - 56 |
| 20 - Right back - Sony Michel | Dameon Pierce - Right back - 31 |
| 74 - OL - Storm Norton | Troy Hairston - Left back - 34 |
| 30 - Right back - Austin Ekeler | Jalen Reeves-Maybin - Left back - 44 |
| 56 - DE - Morgan Fox | Maliek Collins - DT - 96 |
| 1 - WR - DeAndre Carter | Brandin Cooks - WR - 13 |
| 3 - DB - Derwin James Jr. | Phillip Dorsett - WR - 4 |
| 24 - DB - Nasir Adderley | Steven Nelson - Center back - 21 |
| 63 - Center - Corey Linsley | A.J. Cann - OG - 60 |
| 71 - OG - Matt Feiler | Laremy Tunsil - OL - 78 |
| 69 - DL - Sebastian Joseph-Day | Neville Hewitt - Left back - 43 |
| 16 - Pivot - J.K. Scott | Rex Burkhead - Right back - 28 |
| 27 - DB - JC Jackson | Jerry Hughes - DE - 55 |
| 43 - DB - Michael Davis | Eric Murray - Center back - 23 |
| 77 - Guard - Zion Johnson | Chris Moore - WR - 15 |
| 95 - DT - Christian Covington | Ka'imi Fairbairn - K - 15 |
| 23 - Center back - Bryce Callahan | Justin McCray - OL - 64 |
| 42 - Left back - Troy Reeder | Christian Kirksey - Left back - 58 |
| 52 - Left back - Khalil Mack | O.J. Howard - TE - 83 |
| 81 - WR - Mike Williams | Kamu Grugier-Hill - Left back - 51 |
| Substitutes | |