Stadium: Eddie G. Robinson Memorial Stadium Round: 1
Home Manager: Hue Jackson Away Manager:
| NCAAF | 2022/11/26 19:00 | Grambling State v Southern | L | 17-34 |
| NCAAF | 2022/11/13 00:00 | Grambling State v Texas Southern Tigers | L | 7-41 |
| NCAAF | 2022/11/05 19:00 | Arkansas Pine Bluff v Grambling State | W | 10-36 |
| NCAAF | 2022/10/29 19:00 | Alcorn State v Grambling State | W | 6-35 |
| NCAAF | 2022/10/15 18:00 | Florida A&M v Grambling State | L | 20-16 |
| NCAAF | 2022/10/08 18:00 | Grambling State v Alabama A&M | L | 31-37 |
| NCAAF | 2022/10/01 23:00 | Prairie View v Grambling State | L | 34-14 |
| NCAAF | 2022/09/24 18:00 | Grambling State v Bethune Cookman | L | 19-36 |
| NCAAF | 2022/09/03 23:00 | Southern v Florida Memorial University Lions | L | 86-0 |
| NCAAF | 2022/08/27 20:00 | Florida Memorial University Lions v Edward Waters Tigers | W | 39-34 |