| USA MLS Next Pro League | 2022/06/19 18:00 | Philadelphia Union II v Chicago Fire II | D | 1-1 |
| USA MLS Next Pro League | 2022/04/24 23:00 | Chicago Fire II v Philadelphia Union II | D | 3-3 |
| USA MLS Next Pro League | 2022/09/18 19:00 | Chicago Fire II v Inter Miami CF II | W | 1-0 |
| USA MLS Next Pro League | 2022/09/11 21:00 | FC Cincinnati II v Chicago Fire II | W | 0-2 |
| USA MLS Next Pro League | 2022/09/04 00:30 | Columbus Crew II v Chicago Fire II | L | 3-1 |
| USA MLS Next Pro League | 2022/08/26 00:00 | Chicago Fire II v Toronto FC II | W | 2-1 |
| USA MLS Next Pro League | 2022/08/21 00:00 | Chicago Fire II v New York City FC II | W | 5-0 |
| USA MLS Next Pro League | 2022/08/14 22:00 | New England Revolution II v Chicago Fire II | L | 1-0 |
| USA MLS Next Pro League | 2022/08/07 01:00 | St Louis City II v Chicago Fire II | L | 2-1 |
| USA MLS Next Pro League | 2022/07/30 23:00 | RNY FC v Chicago Fire II | D | 1-1 |
| USA MLS Next Pro League | 2022/09/24 23:00 | Toronto FC II v Philadelphia Union II | L | 1-0 |
| USA MLS Next Pro League | 2022/09/18 19:00 | New England Revolution II v Philadelphia Union II | W | 1-3 |
| USA MLS Next Pro League | 2022/09/11 17:00 | Philadelphia Union II v Orlando City II | W | 6-1 |
| USA MLS Next Pro League | 2022/09/04 19:30 | Philadelphia Union II v RNY FC | L | 1-2 |
| USA MLS Next Pro League | 2022/08/27 22:30 | Columbus Crew II v Philadelphia Union II | L | 2-0 |
| USA MLS Next Pro League | 2022/08/24 23:00 | New York City FC II v Philadelphia Union II | W | 1-2 |
| USA MLS Next Pro League | 2022/08/21 23:00 | Philadelphia Union II v New England Revolution II | W | 5-1 |
| USA MLS Next Pro League | 2022/08/14 22:00 | Philadelphia Union II v Inter Miami CF II | D | 2-2 |