Stadium: Scotiabank Arena
Home Manager: Jay Woodcroft Away Manager: Sheldon Keefe
| NHL | 2022/01/06 00:00 | EDM Oilers v TOR Maple Leafs | L | 2-4 |
| NHL | 2021/12/15 02:00 | TOR Maple Leafs v EDM Oilers | L | 5-1 |
| NHL | 2021/03/29 23:00 | EDM Oilers v TOR Maple Leafs | W | 3-2 |
| NHL | 2021/03/27 23:00 | EDM Oilers v TOR Maple Leafs | L | 3-4 |
| NHL | 2021/03/04 01:00 | TOR Maple Leafs v EDM Oilers | L | 6-1 |
| NHL | 2021/03/02 03:00 | TOR Maple Leafs v EDM Oilers | L | 3-0 |
| NHL | 2021/02/28 00:00 | TOR Maple Leafs v EDM Oilers | L | 4-0 |
| NHL | 2021/01/31 00:00 | TOR Maple Leafs v EDM Oilers | W | 3-4 |
| NHL | 2022/11/24 00:30 | EDM Oilers v NY Islanders | L | 0-3 |
| NHL | 2022/11/22 00:00 | EDM Oilers v NJ Devils | L | 2-5 |
| NHL | 2022/11/20 03:00 | VGS Golden Knights v EDM Oilers | W | 3-4 |
| NHL | 2022/11/17 03:00 | LA Kings v EDM Oilers | L | 3-1 |
| NHL | 2022/11/12 21:00 | EDM Oilers v FLA Panthers | W | 4-2 |
| NHL | 2022/11/11 00:00 | EDM Oilers v CAR Hurricanes | L | 2-7 |
| NHL | 2022/11/09 00:30 | EDM Oilers v TB Lightning | W | 3-2 |
| NHL | 2022/11/08 01:00 | EDM Oilers v WAS Capitals | L | 4-5 |
| NHL | 2022/11/24 00:00 | TOR Maple Leafs v NJ Devils | W | 2-1 |
| NHL | 2022/11/22 00:30 | NY Islanders v TOR Maple Leafs | L | 3-2 |
| NHL | 2022/11/20 00:00 | BUF Sabres v TOR Maple Leafs | W | 2-5 |
| NHL | 2022/11/18 00:00 | NJ Devils v TOR Maple Leafs | L | 3-2 |
| NHL | 2022/11/16 00:00 | TOR Maple Leafs v PIT Penguins | W | 5-2 |
| NHL | 2022/11/13 00:00 | VAN Canucks v TOR Maple Leafs | W | 2-3 |
| NHL | 2022/11/12 00:00 | PIT Penguins v TOR Maple Leafs | L | 4-2 |
| NHL | 2022/11/09 00:00 | VGS Golden Knights v TOR Maple Leafs | L | 4-3 |