Stadium: Credit Union 1 Arena
Home Manager: Rechelle Turner Away Manager: Ashleen Bracey
| NIT Women | 2022/03/18 00:00 | Murray State (W) v Vanderbilt (W) | L | 47-73 |
| WNCAAB | 2022/03/04 21:30 | Tennessee Tech (W) v Murray State (W) | L | 68-62 |
| WNCAAB | 2022/03/03 21:30 | Murray State (W) v SIU Edwardsville (W) | W | 84-76 |
| WNCAAB | 2022/02/26 20:00 | Murray State (W) v SE Missouri State (W) | W | 86-54 |
| WNCAAB | 2022/02/24 23:00 | Belmont (W) v Murray State (W) | L | 85-79 |
| WNCAAB | 2022/02/19 19:00 | Murray State (W) v Tennessee Martin (W) | W | 69-56 |
| WNCAAB | 2022/02/17 00:00 | Austin Peay Women v Murray State (W) | W | 61-68 |
| WNCAAB | 2022/02/12 19:00 | Murray State (W) v Morehead State (W) | W | 72-58 |
| WNCAAB | 2022/03/02 01:00 | UIC Women v Wisc Milwaukee (W) | L | 46-55 |
| WNCAAB | 2022/02/26 19:00 | Youngstown State (W) v UIC Women | L | 61-54 |
| WNCAAB | 2022/02/24 22:00 | Robert Morris (W) v UIC Women | L | 57-50 |
| WNCAAB | 2022/02/19 20:00 | UIC Women v Wisc Milwaukee (W) | L | 57-65 |
| WNCAAB | 2022/02/18 01:00 | UIC Women v Wisc Green Bay (W) | L | 46-75 |
| WNCAAB | 2022/02/14 22:00 | Detroit Women v UIC Women | L | 63-61 |
| WNCAAB | 2022/02/12 19:00 | UIC Women v Wright State (W) | L | 63-69 |
| WNCAAB | 2022/02/11 00:00 | UIC Women v Northern Kentucky (W) | L | 57-67 |