Stadium: Banterra Center
Home Manager: Rechelle Turner Away Manager: Kelly Bond-White
| WNCAAB | 2019/12/15 20:00 | Southern Illinois (W) v Murray State (W) | L | 76-66 |
| WNCAAB | 2018/12/18 23:00 | Murray State (W) v Southern Illinois (W) | L | 59-65 |
| NIT Women | 2022/03/18 00:00 | Murray State (W) v Vanderbilt (W) | L | 47-73 |
| WNCAAB | 2022/03/04 21:30 | Tennessee Tech (W) v Murray State (W) | L | 68-62 |
| WNCAAB | 2022/03/03 21:30 | Murray State (W) v SIU Edwardsville (W) | W | 84-76 |
| WNCAAB | 2022/02/26 20:00 | Murray State (W) v SE Missouri State (W) | W | 86-54 |
| WNCAAB | 2022/02/24 23:00 | Belmont (W) v Murray State (W) | L | 85-79 |
| WNCAAB | 2022/02/19 19:00 | Murray State (W) v Tennessee Martin (W) | W | 69-56 |
| WNCAAB | 2022/02/17 00:00 | Austin Peay (W) v Murray State (W) | W | 61-68 |
| WNCAAB | 2022/02/12 19:00 | Murray State (W) v Morehead State (W) | W | 72-58 |
| NIT Women | 2022/03/16 23:00 | Southern Illinois (W) v Purdue (W) | L | 60-82 |
| WNCAAB | 2022/03/12 19:30 | Illinois State Women v Southern Illinois (W) | L | 50-42 |
| WNCAAB | 2022/03/11 18:00 | Indiana State (W) v Southern Illinois (W) | W | 61-77 |
| WNCAAB | 2022/03/05 19:00 | Southern Illinois (W) v Valparaiso Women | L | 54-67 |
| WNCAAB | 2022/03/04 00:00 | Southern Illinois (W) v Loyola Chicago (W) | W | 51-28 |
| WNCAAB | 2022/02/26 20:00 | Evansville (W) v Southern Illinois (W) | W | 66-80 |
| WNCAAB | 2022/02/25 00:00 | Indiana State (W) v Southern Illinois (W) | W | 46-63 |
| WNCAAB | 2022/02/20 20:00 | Southern Illinois (W) v Illinois State Women | W | 65-49 |