Stadium: UPMC Cooper Fieldhouse
Home Manager: Keith Dambrot Away Manager: Josh Schertz
| NCAAB | 2022/03/04 00:00 | Indiana State v Illinois St | L | 53-58 |
| NCAAB | 2022/02/26 21:00 | Indiana State v Illinois St | L | 66-86 |
| NCAAB | 2022/02/24 00:00 | Northern Iowa v Indiana State | L | 88-82 |
| NCAAB | 2022/02/22 01:00 | Indiana State v Drake | L | 58-74 |
| NCAAB | 2022/02/19 18:00 | Southern Illinois v Indiana State | L | 76-72 |
| NCAAB | 2022/02/16 01:00 | Indiana State v Missouri State | L | 70-79 |
| NCAAB | 2022/02/12 18:00 | Illinois St v Indiana State | W | 57-60 |
| NCAAB | 2022/02/11 00:00 | Indiana State v Evansville | W | 80-77 |
| NCAAB | 2022/03/09 20:30 | Duquesne v Rhode Island | L | 77-79 |
| NCAAB | 2022/03/05 19:00 | La Salle v Duquesne | L | 85-76 |
| NCAAB | 2022/03/03 00:00 | Duquesne v George Washington | L | 93-98 |
| NCAAB | 2022/02/26 17:30 | Duquesne v Rhode Island | L | 54-70 |
| NCAAB | 2022/02/24 00:00 | Davidson v Duquesne | L | 74-50 |
| NCAAB | 2022/02/19 23:00 | Duquesne v St. Bonaventure | L | 55-81 |
| NCAAB | 2022/02/17 00:30 | George Washington v Duquesne | L | 73-52 |
| NCAAB | 2022/02/15 00:00 | Duquesne v Davidson | L | 61-72 |