Stadium: Abbey Stadium Round: 8
Referee: David Rock Home Manager: Mark Bonner Away Manager: Ralph Hasenhuttl
| Club Friendly List | 2022/07/16 12:00 | Cambridge Utd v Notts County | W | 2-0 |
| Club Friendly List | 2022/07/09 12:00 | Cardiff v Cambridge Utd | L | 3-2 |
| England League 1 | 2022/04/30 11:30 | Cambridge Utd v Cheltenham | D | 2-2 |
| England League 1 | 2022/04/23 14:00 | Sunderland v Cambridge Utd | L | 5-1 |
| England League 1 | 2022/04/19 18:45 | Cambridge Utd v Charlton | L | 0-2 |
| England League 1 | 2022/04/16 16:15 | Wigan v Cambridge Utd | W | 1-2 |
| England League 1 | 2022/04/09 14:00 | Cambridge Utd v Morecambe | W | 2-1 |
| England League 1 | 2022/04/05 18:45 | Cambridge Utd v Wycombe | L | 1-4 |
| Elite Club Friendlies | 2022/07/18 17:00 | Austria Klagenfurt v Southampton | D | 0-0 |
| Elite Club Friendlies | 2022/07/16 12:00 | RB Leipzig v Southampton | L | 3-1 |
| England Premier League | 2022/05/22 15:00 | Leicester v Southampton | L | 4-1 |
| England Premier League | 2022/05/17 18:45 | Southampton v Liverpool | L | 1-2 |
| England Premier League | 2022/05/07 14:00 | Brentford v Southampton | L | 3-0 |
| England Premier League | 2022/04/30 14:00 | Southampton v Crystal Palace | L | 1-2 |
| England Premier League | 2022/04/24 13:00 | Brighton v Southampton | D | 2-2 |
| England Premier League | 2022/04/21 18:45 | Burnley v Southampton | L | 2-0 |