[4] Duke 38-31 Siu Hang Lam [9] 2022-07-27 13:00
Stadium: Alumni Stadium Round: 1
Home Manager: Jeff Hafley Away Manager: Mike Elko
Head to Head
| NCAAF | 2020/09/19 16:00 | Boston College v Duke | L | 26-6 |
| NCAAF | 2015/10/03 19:30 | Duke v Boston College | W | 9-7 |
| NCAAF | 2011/09/17 12:00 | Boston College v Duke | W | 19-20 |
| NCAAF | 2010/11/13 12:00 | Duke v Boston College | L | 16-21 |
| NCAAF | 2006/11/11 12:00 | Boston College v Duke | L | 28-7 |
Home History
| NCAAF | 2021/11/27 17:30 | Miami Florida v Duke | L | 47-10 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | L | 62-22 |
| NCAAF | 2021/11/13 20:30 | Duke v Virginia Tech | L | 17-48 |
| NCAAF | 2021/11/06 16:00 | Pittsburgh v Duke | L | 54-29 |
| NCAAF | 2021/10/30 20:00 | Duke v Wake Forest | L | 7-45 |
| NCAAF | 2021/10/16 16:30 | Duke v Virginia | L | 0-48 |
| NCAAF | 2021/10/09 16:30 | Georgia Tech v Duke | L | 31-27 |
| NCAAF | 2021/10/02 16:00 | Duke v North Carolina | L | 7-38 |
Away History
| NCAAF | 2021/11/27 17:00 | Wake Forest v Boston College | L | 41-10 |
| NCAAF | 2021/11/20 17:00 | Florida State v Boston College | L | 26-23 |
| NCAAF | 2021/11/13 20:30 | Boston College v Georgia Tech | W | 41-30 |
| NCAAF | 2021/11/05 23:30 | Virginia Tech v Boston College | W | 3-17 |
| NCAAF | 2021/10/30 19:30 | Boston College v Syracuse | L | 6-21 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | L | 14-28 |
| NCAAF | 2021/10/16 23:30 | NC State v Boston College | L | 33-7 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | L | 13-19 |
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