| Uruguay Reserve League | 2022/05/10 18:00 | Defensor Sporting Reserves v Cerrito Reserves | W | 3-1 |
| Uruguay Reserve League | 2022/05/02 18:00 | Defensor Sporting Reserves v Atletico Fenix Reserves | L | 0-2 |
| Uruguay Reserve League | 2022/04/05 19:00 | Defensor Sporting Reserves v Atletico River Plate Reserves | L | 0-2 |
| Uruguay Reserve League | 2022/03/29 19:00 | Boston River Reserves v Defensor Sporting Reserves | D | 1-1 |
| Uruguay Reserve League | 2022/03/22 18:00 | Defensor Sporting Reserves v Plaza Colonia Reserves | W | 3-0 |
| Uruguay Reserve League | 2022/03/15 19:30 | Montevideo Wanderers Reserves v Defensor Sporting Reserves | L | 3-1 |
| Uruguay Reserve League | 2022/03/01 19:30 | Defensor Sporting Reserves v Torque Reserves | L | 2-3 |
| Uruguay Reserve League | 2022/02/14 19:30 | Defensor Sporting Reserves v Liverpool Montevideo Reserves | L | 1-2 |
| Uruguay Reserve League | 2022/05/09 18:00 | Boston River Reserves v Deportivo Maldonado Reserves | D | 0-0 |
| Uruguay Reserve League | 2022/05/03 17:00 | Deportivo Maldonado Reserves v Plaza Colonia Reserves | D | 1-1 |
| Uruguay Reserve League | 2022/04/29 14:00 | Montevideo Wanderers Reserves v Deportivo Maldonado Reserves | W | 2-3 |
| Uruguay Reserve League | 2022/04/05 18:00 | Deportivo Maldonado Reserves v Torque Reserves | L | 2-4 |
| Uruguay Reserve League | 2022/03/29 19:00 | Penarol Reserves v Deportivo Maldonado Reserves | L | 3-1 |
| Uruguay Reserve League | 2022/03/22 19:00 | Deportivo Maldonado Reserves v Liverpool Montevideo Reserves | L | 2-3 |
| Uruguay Reserve League | 2022/03/15 19:30 | Rentistas Reserves v Deportivo Maldonado Reserves | L | 1-0 |
| Uruguay Reserve League | 2022/03/01 19:30 | Cerrito Reserves v Deportivo Maldonado Reserves | L | 2-1 |