Stadium: Corbett Sports Center
Home Manager: Clarisse Garcia Away Manager: Tarrell Robinson
| WNCAAB | 2021/03/06 19:00 | USC Upstate (W) v Charleston Southern (W) | L | 72-64 |
| WNCAAB | 2021/02/21 18:00 | Charleston Southern (W) v Radford (W) | L | 67-76 |
| WNCAAB | 2021/02/20 19:00 | Radford (W) v Charleston Southern (W) | L | 74-73 |
| WNCAAB | 2021/02/13 20:00 | Longwood (W) v Charleston Southern (W) | L | 76-51 |
| WNCAAB | 2021/02/13 00:00 | Longwood (W) v Charleston Southern (W) | L | 94-48 |
| WNCAAB | 2021/02/06 23:00 | Charleston Southern (W) v High Point (W) | L | 54-71 |
| WNCAAB | 2021/02/06 00:00 | Charleston Southern (W) v High Point (W) | L | 65-88 |
| WNCAAB | 2021/01/30 18:00 | Winthrop (W) v Charleston Southern (W) | L | 53-48 |
| WNCAAB | 2021/03/21 20:00 | North Carolina A&T (W) v NC State (W) | L | 58-79 |
| WNCAAB | 2021/03/13 21:30 | Howard Women v North Carolina A&T (W) | W | 57-59 |
| WNCAAB | 2021/03/12 19:00 | North Carolina A&T (W) v Morgan State Women | W | 69-54 |
| WNCAAB | 2021/02/28 19:00 | North Carolina A&T (W) v North Carolina Central (W) | W | 78-56 |
| WNCAAB | 2021/02/27 19:00 | North Carolina A&T (W) v North Carolina Central (W) | W | 84-54 |
| WNCAAB | 2021/02/21 19:00 | Norfolk State (W) v North Carolina A&T (W) | L | 65-54 |
| WNCAAB | 2021/02/20 19:00 | Norfolk State (W) v North Carolina A&T (W) | W | 60-65 |
| WNCAAB | 2021/02/14 19:00 | North Carolina Central (W) v North Carolina A&T (W) | W | 62-72 |