[5] Michigan 33-37 Michigan State [8] 2021-08-05 00:00
Stadium: Spartan Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | L | 27-24 |
| NCAAF | 2019/11/16 17:00 | Michigan State v Michigan | W | 10-44 |
| NCAAF | 2018/10/20 16:00 | Michigan v Michigan State | W | 21-7 |
| NCAAF | 2017/10/07 23:30 | Michigan State v Michigan | L | 14-10 |
| NCAAF | 2016/10/29 16:00 | Michigan v Michigan State | W | 32-23 |
| NCAAF | 2015/10/17 19:30 | Michigan v Michigan State | L | 23-27 |
| NCAAF | 2014/10/25 19:30 | Michigan State v Michigan | L | 35-11 |
| NCAAF | 2012/10/20 12:00 | Michigan v Michigan State | W | 12-10 |
Home History
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
| NCAAF | 2020/11/22 00:30 | Michigan v Rutgers | W | 48-42 |
| NCAAF | 2020/11/15 00:30 | Wisconsin v Michigan | L | 49-11 |
| NCAAF | 2020/11/07 17:00 | Michigan v Indiana | L | 21-38 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | L | 27-24 |
| NCAAF | 2020/10/24 23:30 | Michigan v Minnesota | W | 49-24 |
| NCAAF | 2020/01/01 18:00 | Michigan v Alabama | L | 16-35 |
| NCAAF | 2019/11/30 17:00 | Ohio State v Michigan | L | 56-27 |
Away History
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | L | 24-39 |
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | L | 52-12 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | W | 20-29 |
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | L | 24-0 |
| NCAAF | 2020/11/07 17:00 | Michigan State v Iowa | L | 7-49 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | W | 27-24 |
| NCAAF | 2020/10/24 16:00 | Rutgers v Michigan State | L | 38-27 |
| NCAAF | 2019/12/27 20:20 | Michigan State v Wake Forest | W | 27-21 |
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