Head to Head
| England Premier League 2 | 2021/10/25 18:00 | Reading U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2019/03/01 19:00 | Southampton U23 v Reading U23 | L | 1-2 |
| England Premier League 2 | 2018/09/29 12:00 | Reading U23 v Southampton U23 | L | 2-0 |
| England Premier League 2 | 2017/12/18 12:30 | Reading U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2017/01/06 13:00 | Reading U23 v Southampton U23 | L | 4-2 |
| England EFL Trophy | 2016/12/21 19:00 | Southampton U23 v Reading U23 | L | 4-5 |
| England Premier League 2 | 2016/09/12 18:00 | Southampton U23 v Reading U23 | W | 3-1 |
Home History
| England Premier League 2 | 2021/11/28 14:00 | Southampton U23 v West Brom U23 | W | 3-1 |
| England U23 Premier League Cup | 2021/11/24 19:00 | Southampton U23 v Bournemouth U23 | W | 1-0 |
| England Premier League 2 | 2021/11/21 12:00 | Sunderland U23 v Southampton U23 | L | 3-2 |
| England Premier League 2 | 2021/11/05 12:00 | Southampton U23 v Newcastle U23 | W | 5-0 |
| England Premier League 2 | 2021/10/31 14:00 | Southampton U23 v Aston Villa U23 | W | 4-0 |
| England Premier League 2 | 2021/10/25 18:00 | Reading U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2021/10/18 11:00 | Wolverhampton U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2021/10/01 15:00 | Southampton U23 v Stoke U23 | D | 1-1 |
Away History
| England Premier League 2 | 2021/12/03 15:00 | Norwich U23 v Reading U23 | L | 5-2 |
| England Premier League 2 | 2021/11/29 19:00 | Reading U23 v Middlesbrough U23 | W | 2-1 |
| England Premier League 2 | 2021/11/22 19:00 | West Brom U23 v Reading U23 | D | 1-1 |
| England U23 Premier League Cup | 2021/11/15 19:00 | Derby U23 v Reading U23 | L | 2-1 |
| England Premier League 2 | 2021/11/08 19:00 | Reading U23 v Aston Villa U23 | D | 2-2 |
| England Premier League 2 | 2021/11/01 19:00 | Reading U23 v Sunderland U23 | L | 0-3 |
| England Premier League 2 | 2021/10/25 18:00 | Reading U23 v Southampton U23 | L | 0-1 |
| England Premier League 2 | 2021/10/15 18:00 | Fulham U23 v Reading U23 | L | 3-0 |
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