[14] Southampton 1-1 Tottenham [5] 2021-10-31 07:00
Stadium: St. Mary's Stadium Round: 20
Referee: Anthony Taylor Home Manager: Ralph Hasenhuttl Away Manager: Antonio Conte
Head to Head
| England Premier League | 2021/04/21 17:00 | Tottenham v Southampton | L | 2-1 |
| England Premier League | 2020/09/20 11:00 | Southampton v Tottenham | L | 2-5 |
| England FA Cup | 2020/02/05 19:45 | Tottenham v Southampton | L | 3-2 |
| England FA Cup | 2020/01/25 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2020/01/01 15:00 | Southampton v Tottenham | W | 1-0 |
| England Premier League | 2019/09/28 14:00 | Tottenham v Southampton | L | 2-1 |
| England Premier League | 2019/03/09 15:00 | Southampton v Tottenham | W | 2-1 |
| England Premier League | 2018/12/05 20:00 | Tottenham v Southampton | L | 3-1 |
Home History
| England Premier League | 2021/10/30 14:00 | Watford v Southampton | W | 0-1 |
| England EFL Cup | 2021/10/26 18:45 | Chelsea v Southampton | L | 5-4 |
| England Premier League | 2021/10/23 14:00 | Southampton v Burnley | D | 2-2 |
| England Premier League | 2021/10/16 14:00 | Southampton v Leeds | W | 1-0 |
| England Premier League | 2021/10/02 14:00 | Chelsea v Southampton | L | 3-1 |
| England Premier League | 2021/09/26 13:00 | Southampton v Wolverhampton | L | 0-1 |
| England EFL Cup | 2021/09/21 18:45 | Sheff Utd v Southampton | W | 4-6 |
| England Premier League | 2021/09/18 14:00 | Man City v Southampton | D | 0-0 |
Away History
| England Premier League | 2021/10/30 16:30 | Tottenham v Man Utd | L | 0-3 |
| England EFL Cup | 2021/10/27 18:45 | Burnley v Tottenham | W | 0-1 |
| England Premier League | 2021/10/24 13:00 | West Ham v Tottenham | L | 1-0 |
| UEFA Conference League | 2021/10/21 16:45 | Vitesse v Tottenham | L | 1-0 |
| England Premier League | 2021/10/17 15:30 | Newcastle v Tottenham | W | 2-3 |
| England Premier League | 2021/10/03 13:00 | Tottenham v Aston Villa | W | 2-1 |
| UEFA Conference League | 2021/09/30 19:00 | Tottenham v NS Mura | W | 5-1 |
| England Premier League | 2021/09/26 15:30 | Arsenal v Tottenham | L | 3-1 |
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