Stadium: Sandy Park Round: 3
Referee: Matthew Carley Home Manager: Robert Baxter Away Manager: John Kingston
| Prem Rugby | 2016/05/07 14:30 | Harlequins v Exeter Chiefs | W | 24-62 |
| Prem Rugby | 2015/11/28 15:00 | Exeter Chiefs v Harlequins | W | 26-25 |
| Prem Rugby | 2015/02/21 15:00 | Harlequins v Exeter Chiefs | W | 21-32 |
| Prem Rugby | 2014/09/28 13:00 | Exeter Chiefs v Harlequins | W | 36-13 |
| Prem Rugby | 2016/05/28 14:00 | Saracens v Exeter Chiefs | L | 28-20 |
| Prem Rugby | 2016/05/21 14:15 | Exeter Chiefs v Wasps | W | 34-23 |
| Prem Rugby | 2016/05/07 14:30 | Harlequins v Exeter Chiefs | W | 24-62 |
| Prem Rugby | 2016/05/01 12:00 | Exeter Chiefs v Wasps | W | 24-3 |
| Prem Rugby | 2016/04/15 18:45 | Gloucester v Exeter Chiefs | L | 16-9 |
| European Rugby Champions Cup | 2016/04/09 14:15 | Wasps v Exeter Chiefs | L | 25-24 |
| Prem Rugby | 2016/04/02 14:00 | Exeter Chiefs v Worcester Warriors | W | 50-12 |
| Prem Rugby | 2016/03/26 15:15 | Saracens v Exeter Chiefs | L | 36-18 |
| European Rugby Challenge Cup | 2016/05/13 19:00 | Harlequins v Montpellier | L | 19-26 |
| Prem Rugby | 2016/05/07 14:30 | Harlequins v Exeter Chiefs | L | 24-62 |
| Prem Rugby | 2016/05/01 14:00 | London Irish v Harlequins | W | 25-32 |
| European Rugby Challenge Cup | 2016/04/22 18:45 | Harlequins v Grenoble | W | 30-6 |
| Prem Rugby | 2016/04/16 14:15 | Saracens v Harlequins | L | 22-12 |
| European Rugby Challenge Cup | 2016/04/09 19:05 | Harlequins v London Irish | W | 38-30 |
| Prem Rugby | 2016/04/02 14:00 | Harlequins v Newcastle Red Bulls | W | 46-25 |
| Premiership Rugby Shield | 2016/03/28 18:30 | Saracens Storm v Harlequins | L | 28-21 |